Reducing Agents
Cysteamine Hydrochloride
Catalog ID | Size | Pricing | |
---|---|---|---|
C-122-100 | 4 x 25 g | $ 139.00 | |
C-122-25 | 25 g | $ 139.00 |
Description
Cysteamine Hydrochloride or cysteamine is a mercaptoethylamine hydrochloride salt reductant that forms in mammals from pantetheine formation by degrading Coenzyme A. It has been used as a cystine depleting agent as well as a somatostatin inhibitor.
Cysteamine has been shown in vivo to remove accumulated cystine in lysosomes by forming disulfide bridges with cystine. The interaction between cysteamine and cystine forms cysteine and cysteine-cysteamine mixed disulfide which can freely exit lysosomes.
Cysteamine has also been shown to inhibit somatostatin however, the mechanism of action has not been elucidated. It is believed to either inhibit somatostatin precursor formation or by promoting somatostatin degradation.
Product Specifications
Catalog ID | C-122 |
---|---|
CAS # | 156-57-0 |
MW | 113.61 g/mol |
Storage/Handling | Store desiccated at 4°C. |
DTE (Dithioerythritol)
Catalog ID | Size | Pricing | |
---|---|---|---|
D-260-25 | 25 g | $ 240.00 | |
D-260-50 | 50 g | $ 438.00 | |
D-260-100 | 100 g | $ 775.00 | |
D-260-250 | 250 g | $ 1,785.00 |
Description
Dithioerythritol (DTE) is one of two Cleland's Reagents (along with DTT). The two chemicals are epimers of each other, in which the hydroxyl groups of DTE are in the cis form as opposed to the trans form for DTT.
DTE is a strong reducing agent and is a component of buffers used in protocols for the isolation and purification of proteins.
Product Specifications
Catalog ID | D-260 |
---|---|
CAS # | 6892-68-8 |
MW | 154.25 g/mol |
Grade | MOLECULAR BIOLOGY GRADE |
Storage/Handling | Store desiccated at -20°C. Protect from light. |
DTT (Dithiothreitol) (> 99% pure) Protease free
Catalog ID | Size | Pricing | |
---|---|---|---|
DTT10 | 10 g | $ 67.00 | |
DTT25 | 25 g | $ 140.00 | |
DTT50 | 50 g | $ 247.00 | |
DTT100 | 100 g | $ 397.00 | |
DTT500 | 500 g | $ 1,767.00 |
Description
Dithiothreitol (DTT) is the common name of the more popular of the two Cleland’s Reagents (the other being Dithioerythritol or DTE). DTT is a powerful reducing agent that forms a stable six-membered ring with an internal disulfide bond which is resistant to oxidation. DTT is often used for the following: reducing the disulfide bridge of the cross-linker N,N′-bis(acryloyl) cystamine to break apart the matrix of a polyacrylamide gel, the reduction of disulfide bonds in proteins, the prevention of those bonds from forming between cysteine residues and lastly, DTT is often used to reduce thiolated DNA in order to minimize dimerization.
DTT is a nearly 7-fold stronger reduction agent than βME (β-mercaptoethanol) and has a less offensive odor and is less toxic.
Product Specifications
Catalog ID | DTT |
---|---|
Name(s) |
DTT, DL-Dithiothreitol (Clelands Reagent), (2 S,3S)-1,4-bis(sulfanyl)butane-2,3-diol, D- threo-1,4-dimercapto-2,3-butanediol |
CAS # | 27565-41-9 / 3483-12-3 |
Formula | C4H10O2S2 |
MW | 154.25 g/mol |
Grade | MOLECULAR BIOLOGY GRADE |
PubChem Chemical ID | 19001 |
Storage/Handling | Store desiccated at -20°C. |
Glutathione reduced ethyl ester

Catalog ID | Size | Pricing | |
---|---|---|---|
G-275-500 | 500 mg | $ 357.00 |
Description
Product Specifications
Catalog ID | G-275 |
---|---|
CAS # | 118421-50-4 |
MW | 335.38 g/mol |
Storage/Handling | Store at -20°C. |
Glutathione, Oxidized
Catalog ID | Size | Pricing | |
---|---|---|---|
G-060-1 | 1 g | $ 41.00 | |
G-060-5 | 5 g | $ 78.00 | |
G-060-10 | 10 g | $ 129.00 | |
G-060-25 | 25 g | $ 232.00 | |
G-060-100 | 100 g | $ 535.00 |
Description
Glutathione, Oxidized (GSSG) is the oxidized version of the naturally occurring and very important detoxification agent glutathione (GSH). When used in vivo, GSSG will not remain oxidized, but rather be reduced back to GSH. A ratio of GSH to GSSG can be used to determine the level of oxidative stress that has occurred in cells. When a cell has higher levels of GSSG, then it can be implied that more oxidative stress has occurred within the cell.
Product Specifications
Catalog ID | G-060 |
---|---|
CAS # | 27025-41-8 |
MW | 612.63 g/mol |
Grade | HIGH PURITY GRADE |
Storage/Handling | Store at 4°C. |
L-Glutathione, Reduced
Catalog ID | Size | Pricing | |
---|---|---|---|
G-155-25 | 25 g | $ 92.00 | |
G-155-50 | 50 g | $ 170.00 | |
G-155-100 | 100 g | $ 304.00 | |
G-155-250 | 250 g | $ 521.00 | |
G-155-500 | 500 g | $ 974.00 | |
G-155-1000 | 1 kg | $ 1,818.00 |
Description
L-Glutathione is a co-substrate to glutathione transferase found in plants and animals and is involved in the elimination of free radicals resulting from both cellular respiratory and metabolic activities.
Product Specifications
Catalog ID | G-155 |
---|---|
CAS # | 70-18-8 |
MW | 307.32 g/mol |
Storage/Handling | Store at 4°C. Protect from light. |
TCEP HCl
Catalog ID | Size | Pricing | |
---|---|---|---|
TCEP1 | 1 g | $ 30.00 | |
TCEP2 | 2 g | $ 51.00 | |
TCEP5 | 5 g | $ 92.00 | |
TCEP10 | 10 g | $ 150.00 | |
TCEP25 | 25 g | $ 298.00 | |
TCEP50 | 50 g | $ 545.00 | |
TCEP100 | 100 g | $ 1,067.00 |
Description
TCEP-HCl is an odorless reducing agent suitable for protein applications and in the preparation for electrophoresis. TCEP is water soluble, is stable in a variety of solutions and is particularly useful in the labeling of cysteine residues with maleimides, preventing the cysteines from forming disulfide bonds. As a reducing agent, TCEP has many other desirable features.
Product Specifications
Catalog ID | TCEP |
---|---|
Name(s) |
TCEP-HCl; Tris (2-Carboxyethyl) phosphine Hydrochloride |
CAS # | 51805-45-9 |
Grade | Molecular Biology Grade |
Formula | C9H15O6P • HCl |
MW | 286.65 g/mol |
PubChem Chemical ID | 2734570 |
Storage/Handling | Store desiccated at -20°C. |