M_Products

(S)-(+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid is more commonly known as naproxen. It is a non-steroidal anti-inflammatory agent and non-selective inhibitor of cyclooxygenase (COX-1 and COX-2). Naproxen has been shown to decrease production of thromboxane B2.

1-Methylindole is a reagent used in chemical synthesis. It has been used to synthesize pyrrolidine analogues, PET imaging agents and anticancer agents.

1-O-Methyl-beta-D-galactopyranoside is a beta-D-galactopyranoside and a weak substrate. It is an effective inducer of beta-D-galctosidase and used in the metabolism of 2-deoxygalactose.

1-O-Methyl-β-D-glucuronic acid, sodium salt is an inducer of β-glucuronidase, a glycosidase enzyme coded by the GUS gene.

The GUS gene is the most extensively used reporter gene, particularly in plant biology because it offers the advantage of having no background activity.

β-glucuronidase also has an important role within human digestion because this enzyme is capable of deconjugating toxins within the body and releasing them back freely into the bloodstream. There is a positive relationship between higher levels of β-glucuronidase in the colon and increased cancer risk. However, β-glucuronidase, at certain levels, is necessary, and deficiencies can result in mucopolysaccharidosis type VII or Sly syndrome in newborns.

1-O-Methyl-β-D-glucopyranoside is commonly used to study the specificity of yeast Saccharomyces cerevisiae in removing carbohydrates by fermentation. Additionally, it has been used to analyze alternansucrase acceptor reactions with methyl hexopyranosides.

2'-C-Methylcytidine is a nucleoside analog with antiviral properties. It has shown be a potent replication inhibitor, in vivo, towards multiple RNA viruses including hepatitus C virus (HCV). 2'-C-Methylcytidine has been shown inhibit viral RNA polymerase, disrupting replicon formation and preventing viral proliferation. While 2'-C-Methycytidine is a strong antiviral, it has exhibited low oral bioavailability.

4-MU-NANA is a fluorescent substrate for the enzymatic assay of neuraminidase. In this assay, neuraminidase catalyzes the hydrolyzation of 2'-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid to N-acetylneuraminic acid and 4-Methylumbelliferone, a blue, fluorescent, soluble substance that can be detected fluorometrically.

This product is ideal for sensitively measuring activity and can be used to assess even the slightest amounts of neuraminidase activity in humans. Additionally, it can be used to identify patients who exhibit normal levels of activity or those who are deficient. Lower neuraminidase activity has been observed in cancer patients.

2-Methylhippuric acid is a derivative of hippuric acid. It is found in the urine of individuals infected with the hepatitis B virus, determined using HPLC.

3-O-Methyl-D-glucopyranoside is a glucose that is not metabolized, giving it the ability to study glucose transport capacity in diabetic rats. It has been used as an intermediate in the synthesis of surfactants, resins, emulsifiers and thickening agents.

4-Methoxyindole is used in a variety of preparation procedures. It is a reactant involved in the synthesis of GABA analogs, HIV-1 integrase inhibitors, anticancer agents, sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors, integrase strand-transfer inhibitors (INSTIs), and isomeridianin G. Additionally, it is used in reverse-phase liquid chromatography analysis of the reaction of β-cyclodextrin and pindolol.

4-Methylhippuric acid is has been used as a biological marker to monitor xylene exposure. It can also be used in HPLC to determine the carboxylic acid concentration in urine, along with styrene and ethyl benzene.

4-Methylindole is an indole used as a reagent in chemical synthesis. It has been used in the synthesis of triazolobenzazepine derivatives, anti-cancer phosphonate analogs and color emitting or electroluminescent applications.

4-Methylumbelliferone is useful as an indicator in the determination of nitric acid. It is also useful in the kinetic investigation of enzyme activity. 4-Methylumbelliferone is fluorescent in alkaline solution.

4-Methylumbelliferyl alpha-L-idopyranosiduronic acid sodium salt is a carbohydrate acid and organic sodium salt applied as an indicator. It is the fluorogenic substrate used in assays of α-L-Iduronidase and iduronate-2-sulfatase for identifying Hurler syndrome, also called mucopolysaccharidosis type I (MPS I). The disorder is characterized by α -L iduronidase enzyme deficiency, resulting in the buildup of glucosaminoglycans. Tests measure the chemical products 4-MU-α-IdoA or fluorophate 4-MU emitted following the enzymatic action of 4-Methylumbelliferyl alpha-L-idopyranosiduronic acid sodium salt. The substance is a white crystalline powder and is soluble in ethanol, methanol and water.

4-Methylumbelliferyl caprylate is a fluorogenic substrate for esterase with C8 activity, yielding a blue fluorescent solution upon cleavage and is used for the identification of Salmonella spp. based on the detection of caprylate esterase.

4-Methylumbelliferyl cholin phosphate is a fluorogenic substrate.

4-Methylumbelliferyl nonanoate is a fluorogenic substrate for esterase yielding a blue fluorescent solution upon cleavage. It can be useful for identification of certain Salmonella species.

4-Methylumbelliferyl palmitate is used as a fluorogenic substrate for a subclass of esterases called lipase.

Lipase is an enzyme that assists in the hydrolysis of fats. They have a large role in digestion as well as dietary lipid transport.

Lysosomal acid lipase (LAL), in particular, is required for the hydrolysis of cholesterol esters which are then delivered into the lysosome. Deficiencies in LAL are primarily associated with two diseases: cholesteryl ester storage disease (CESD) and Wolman’s disease (WD). 4-Methylumbelliferyl palmitate has often been used as one of the lipase substrates in studies involving either of these diseases.