Product Description

TCEP (Tris (2-Carboxyethyl) phosphine Hydrochloride) is an odorless reducing agent suitable for protein applications and in the preparation for electrophoresis. TCEP is water soluble, is stable in a variety of solutions and is particularly useful in the labeling of cysteine residues with maleimides, preventing the cysteines from forming disulfide bonds.

TCEP 50 g and 100 g ships as multiple 25 g units to qualify for a small quantity exception to hazardous fees.
Due to hazardous goods restrictions, this product cannot ship by ground shipping to Canada or Mexico.


  • PROTEASE FREE Oxidizing agent
  • TCEP-HCl is stable in air.
  • TCEP-HCl is odorless so reactions can be carried out on the bench instead of the fume hood.
  • TCEP-HCl is efficient and can be used to reduce disulfide bonds at low concentrations.
  • TCEP-HCl is selective for disulfides and does not react with other protein side chains.
  • TCEP-HCl may be used as a substitute for DTT at a final concentration of 50mM.


Store desiccated at -20°C.

Working Concentration

TCEP is commonly stored in a 0.5M stock solution for up to 3 months at -20°C.
Working concentrations are typically around 5-50mM and should be remade daily.

Product Specifications

Catalog ID TCEP
Name(s) TCEP-HCl;
Tris (2-Carboxyethyl) phosphine Hydrochloride
CAS # 51805-45-9
Grade Molecular Biology Grade
Formula C9H15O6P • HCl
MW 286.65 g/mol
PubChem Chemical ID 2734570
Storage/Handling Store desiccated at -20°C.

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$12.99 Ground shipping (In continental US only.)

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