M_Products
BTC, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
1370-12-5 | 5 μg | $ 115.00 |
Description
BTC (Betacellulin) is an EGF related growth factor containing 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. It was originally isolated from the MCF-7 human breast carcinoma cell line and it is expressed in most tissues including kidney, uterus, liver and pancreas. BTC is also present in body fluids, including serum, milk, and colostrum. BTC is a ligand for the receptors erbB1 and erbB4. It is synthesized as a transmembrane protein and the ectodomain is cleaved by a protease to release the mature protein. BTC exhibits mitogenic activity for retinal pigment epithelial cells and vascular smooth muscle cells. It also exhibits growth-promoting activity that is similar to that of EGF.
Product Specifications
Catalog ID | 1370-12 |
---|---|
MW | ~9.0 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL11, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-11-5 | 5 μg | $ 115.00 |
Description
Murine CCL11 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed in fibroblasts, epithelial cells, smooth muscle cells, and dendritic cells. Expression of CCL11 is upregulated by several proinflammatory cytokines, including IL1A and TNFA, and is inhibited by IFNG. It is strongly and selectively chemotactic for eosinophils and induces a calcium flux response in eosinophils. CCL11 is involved in a variety of eosinophilic inflammatory diseases. CCL11 is a ligand primarily for CCR3, but also CCR1, CCR2, CCR5, and ACKR2 (D6).
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Product Specifications
Catalog ID | 2340-11 |
---|---|
MW | ~8.4 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL12, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-12-5 | 5 μg | $ 115.00 |
Description
Murine CCL12 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed by macrophages and in lymph nodes and thymus tissue. Expression of CCL12 is upregulated after hypoxia and during bacterial infection and allergic inflammation. It is chemotactic for peripheral blood monocytes and fibrocytes and may play a critical role in the early stages of inflammation, as well as in joint and growth plate development. CCL12 is a ligand for CCR2.
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Product Specifications
Catalog ID | 2340-12 |
---|---|
MW | ~9.3 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL17, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-17-5 | 5 μg | $ 115.00 | |
2340-17-100 | 100 μg | $ 745.00 | |
2340-17-500 | 500 μg | $ 1,539.00 |
Description
CCL17 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed constitutively in the thymus and lymph nodes and transiently in peripheral blood mononuclear cells that have been induced by phytogemagglutinin. It is chemotactic for T-cells and plays a role in T-cell development trafficking, and activation. CCL17 promotes atherosclerosis by restricting the maintenance of regulatory T-cells, thereby limiting their expansion. It is a ligand for CCR4, CCR8, and the erythrocyte receptor ACKR1.
Product Specifications
Catalog ID | 2340-17 |
---|---|
MW | ~7.9 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL19, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-19-5 | 5 μg | $ 115.00 |
Description
CCL19 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed by dendritic cells in lymph nodes, as well as in spleen and thymus tissue. Expression of CCL19 is upregulated by IFNG and TNF-alpha. CCL19 has shown to be chemotactic for T-cells and B-cells, as well as CFU granulocyte macrophages. It plays a role in mobilization of dendritic cells from the epidermis to lymph nodes and development of local lymphoid tissues. CCL19 is a ligand for CCR7 (EBI1), as well as the atypical chemokine receptors CCRL1 and CCRL2.
Product Specifications
Catalog ID | 2340-19 |
---|---|
MW | ~9.2 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL20, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-20-5 | 5 μg | $ 115.00 | |
2340-20-100 | 100 μg | $ 745.00 | |
2340-20-500 | 500 μg | $ 1,539.00 |
Description
CCL20 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed in the liver as well as in lymphocytes, monocytes, and leukemia cells that have been induced by a mediator of inflammation, such as IFNG, IL1B, LPS, or PMA. It is upregulated in psoriasis because of proinflammatory mediators produced in the skin and attracts T lymphocytes to lesions. CCL20 is chemotactic mainly for lymphocytes, but also for granulocytes and immature dendritic cells and it plays a role in development of mucosal lymphoid tissue. It is a ligand for CCR6.
Product Specifications
Catalog ID | 2340-20 |
---|---|
MW | ~8.0 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL21, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-21-5 | 5 μg | $ 115.00 |
Description
CCL21 is a chemokine containing six conserved cysteine residues, two of which are adjacent. Murine CCL21 is encoded by two to three genes, depending on the strain, each product of which differs by a single amino acid and expression of these genes is regulated differentially. It is expressed in high endothelial venules of lymph nodes, as well as lung, spleen, tonsils, breast stromal cells, and a variety of other cells. Murine CCL21-Leu is expressed predominantly in the lung independent of an inducer. Expression of CCL21 is inhibited by IFNG. It is chemotactic for peripheral blood lymphocytes and plays a major role in initiation and expansion of adaptive immune responses, as well as development of local lymphoid tissue. CCL21 is a ligand for CCR7, as well as CXCR3 and the virorecptor M3.
Product Specifications
Catalog ID | 2340-21 |
---|---|
MW | ~12.1 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL22, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-22-5 | 5 μg | $ 115.00 |
Description
Murine CCL22 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed in activated splenic B-cells, macrophages, and dendritic cells. Expression of CCL22 is induced by IL4 and IL13 and inhibited by IL10. Increased expression of murine CCL22 has also been observed from bone marrow-derived mast cells after incubation with TNF-alpha or IgE. CCL22 is chemotactic for chronically activated T-cells and plays a role in trafficking activated T cells. It also plays a role in migration and survival of cells expressing FOXP3 in HTLV1 infection. CCL22 is a ligand for CCR4.
Product Specifications
Catalog ID | 2340-22 |
---|---|
MW | ~7.8 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL24, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-24-5 | 5 μg | $ 115.00 |
Description
CCL24 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed by activated monocytes and activated T lymphocytes. Murine CCL24 is expressed in jejunum and spleen constitutively and is upregulated by allergen challenge and IL4 overexpression. CCL24 is chemotactic for resting T lymphocytes and eosinophils and is a suppressor of HPP-CFC myeloid progenitor cells. It causes a transient rise in intracellular calcium levels in eosinophils. CCL24 is a ligand for CCR3.
Product Specifications
Catalog ID | 2340-24 |
---|---|
MW | ~10.3 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL25, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-25-5 | 5 μg | $ 115.00 |
Description
CCL25 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed primarily by thymic dendritic cells and in small intestine tissue. CCL25 is chemotactic for thymocytes, macrophages, and dendritic cells, as well as IgA antibody-secreting cells and is also a suppressor of myeloid progenitor cells. CCL25 is important for selective homing and retention of T-cells in the small intestine instead of the colon and is possibly involved in T-cell development. It also promotes migration of various types of cancer cells. CCL25 is a ligand for CCR9 and ACKR4.
Product Specifications
Catalog ID | 2340-25 |
---|---|
MW | ~14.1 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL27, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-27-5 | 5 μg | $ 115.00 |
Description
CCL27 is a chemokine containing four conserved cysteine residues, two of which are adjacent. As a result of alternative splicing, there are two isoforms of CCL27, each containing a different signal sequence. One variant is expressed in the skin and the placenta and is secreted, while the other is expressed in the testes and brain and targeted to the nucleus to participate in intracrine signaling. This recombinant murine CCL27 is a mature form that lacks a secretion signal sequence or a nuclear targeting sequence. Expression of CCL27 is upregulated by TNF-alpha and IL1B. CCL27 is chemotactic for CLA(+) T-cells and plays a role in T-cell migration in the skin. The intracrine isoform may play a role in cell migration as well by inducing cytoskeletal relaxation. CCL27 is a ligand for CCR10.
Product Specifications
Catalog ID | 2340-27 |
---|---|
MW | ~10.9 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL28, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-28-5 | 5 μg | $ 115.00 |
Description
Murine CCL28 is a chemokine containing six conserved cysteine residues, two of which are adjacent. It is expressed constitutively in epithelial cells at mucosal sites such as salivary glands and colon and expression is upregulated by proinflammatory stimuli such as IL1 and n-butyrate. CCL28 is chemotactic for resting T-cells, eosinophils, and IgA antibody-secreting cells (ASCs). It is important for regulating IgA ASC accumulation in mammary glands and consequently the transfer of IgA antibodies from mother to infant. Tumor hypoxia causes HIF1α induced expression of CCL28 and subsequent migration of T-cells, promoting tumor tolerance to antigens and angiogenesis. CCL28 is a ligand for CCR10 and CCR3.
Product Specifications
Catalog ID | 2340-28 |
---|---|
MW | ~12.6 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL3, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-03-10 | 10 μg | $ 165.00 |
Description
Murine CCL3 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed by T-cells, B-cells, and various tumor cells lines and has been identified as a G0/G1 switch gene in these cells. CCL3 plays an important role in the recruitment and activation of polymorphonuclear leukocytes in the acute inflammatory state, an inhibitory role in hematopoiesis, and displays inhibitory activity against strains of HIV-1, HIV-2, and SIV. CCL3 is a ligand for CCR1, CCR4, and the HIV-1 coreceptor CCR5. Activation of CCR5 through CCL3 activates a G-protein pathway through GNAI2 and a tyrosine phosphorylation through JAK2.
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Product Specifications
Catalog ID | 2340-03 |
---|---|
MW | ~7.9 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL4, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-04-10 | 10 μg | $ 165.00 |
Description
Murine CCl4 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed and secreted by T-cells, B-cells, monocytes, and various tumor cells lines. Expression of CCL4 is induced by IL2 and mitogens, such as phytohemmagglutinin, lipopolysaccharide, and the peptidoglycan wall of S. aureus and expression is inhibited by glucocorticoids, TGF-beta, and cyclosporin A. CCL4 is an HIV-suppressive factor produced by CD8+ T-cells. It also binds to HSV-1 virions and generates pores in the envelope of HSV-1. CCL4 is a ligand for CCR1, CCR3, CCR5, CCR8, and ACKR2 (D6). Murine CCL4 is active on both human and murine hematopoietic cells.
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Product Specifications
Catalog ID | 2340-04 |
---|---|
MW | ~7.8 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL5, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-05-5 | 5 μg | $ 115.00 |
Description
Murine CCL5 is a chemokine containing four conserved cysteine residues, the first two of which are adjacent. It is expressed and secreted by T lymphocytes. Expression of CCL5 is induced by TNF-alpha and IL1-alpha and inhibited by stimulation of T lymphocytes. CCL5 is chemotactic for T lymphocytes, eosinophils, basophils, and monocytes and plays a role in recruiting these cells to inflammatory sites. It also induces proliferation and activation of CHAK cells and is an HSV and HIV-suppressive factor. CCL5 is a ligand for CCR1, CCR3, CCR5, and the viroreceptor M3. Murine CCL5 is chemotactic for both murine and human leukocytes in a dose-dependent fashion.
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Product Specifications
Catalog ID | 2340-05 |
---|---|
MW | ~7.9 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL6, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-06-10 | 10 μg | $ 165.00 |
Description
Murine CCL6 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed primarily in microglia and other macrophages, as well as myelopoietic bone marrow cells. Upregulation of expression of CCL6 has been observed after stimulation with IFNG, CSF1, CSF2, IL3, and IL4. CCL6 expression is also stimulated by IL-13 and is required for IL-13 stimulation of other chemokines. CCL6 is chemotactic for macrophages and lymphocytes and acts as a ligand primarily for CCR1. CCL6 has only been observed in rodents thus far; murine CCL6 is most homologous to human CCL23.
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Product Specifications
Catalog ID | 2340-06 |
---|---|
MW | ~10.7 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL7, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-07-10 | 10 μg | $ 165.00 |
Description
Murine CCL7 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It was first isolated from murine mast cells stimulated by IgE interacting with an antigen and is expressed and secreted by T cells, monocytes, macrophages, and a variety of tumor cell lines. Expression is induced by IFNG and inhibited by IL13. CCL7 is chemotactic for monocytes, macrophages, eosinophils, and NK cells and regulates protease secretion by macrophages which may contribute to metastasis of cancer cells. CCL7 is a ligand primarily for CCR2, but also for CCR1, CCR3, CCR10, and ACKR2 (D6).
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Product Specifications
Catalog ID | 2340-07 |
---|---|
MW | ~8.5 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL8, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-08-5 | 5 μg | $ 115.00 |
Description
Murine CCL8 is a chemokine containing four conserved cysteine residues, the first two of which are adjacent. It is expressed by peripheral blood leukocytes, as well as a variety of other cells. Expression of CCL8 is induced by IFNG, IFNB, IL1B, and various cytokine inducers such as viruses, endotoxins, and mitogens. It is chemotactic for monocytes, lymphocytes, basophils, and eosinophils and plays a role in tumor-associated leukocyte infiltration by recruiting leukocytes to sites of inflammation. CCL8 also inhibits CCR5-mediated HIV-1 entry and replication. CCL8 is a ligand for CCR1, CCR2B, CCR3, CCR5, CCR8, ACKR2, and ACKR4.
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Product Specifications
Catalog ID | 2340-08 |
---|---|
MW | ~8.5 kDa |
Storage/Handling | Store desiccated at -20°C. |
CCL9 (CCL10), Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
2340-09-5 | 5 μg | $ 115.00 |
Description
CCL9 is a chemokine containing six conserved cysteine residues that form three disulfide bonds essential for biological activity. It circulates in the blood of healthy animals and is expressed constitutively in macrophages and myeloid cell lines. CCL9 displays chemotaxis for neutrophils, CD4+ T lymphocytes, and Peyer’s patch dendritic cells. Upon injection of CCL9, fever and inflammation are induced. CCL9 plays a major role in osteoclastogenesis and inhibits colony formation of bone marrow myeloid immature progenitors. It is a ligand for CCR1 and CCR3. Murine CCL9 has also been identified as murine CCL10 and is most homologous to Human CCL15.
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Product Specifications
Catalog ID | 2340-09 |
---|---|
MW | ~11.6 kDa |
Storage/Handling | Store desiccated at -20°C. |
CDNF, Murine
Catalog ID | Size | Pricing | |
---|---|---|---|
1370-16-5 | 5 μg | $ 115.00 |
Description
CDNF is a secreted neurotrophic factor that contains 8 conserved cysteine residues, much like its relative MANF. CDNF and its structural homolog MANF each contain an N-terminal saposin-like lipid binding domain and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF is expressed in several tissues, including the embryonic and postnatal brains of mice, as well as the heart, skeletal muscle, and testis. It has been shown to promote survival, growth and function of dopamine specific neurons. CDNF and MANF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease.
Product Specifications
Catalog ID | 1370-16 |
---|---|
MW | ~18.5 kDa |
Storage/Handling | Store desiccated at -20°C. |