R_Products

Macerozyme R-10 is a macerating enzyme from the Rhizopus sp. which is perfectly suited for the isolation of plant cells. Macerozyme R-10 is often used in combination with Cellulase "Onozuka R-10" in the isolation of plant protoplasts.

Midkine (MDK) is a heparin-binding growth factor that is expressed in various cell types during embryo development and in a variety of carcinomas. It is induced by retinoic acid, as well as during oncogenesis, inflammation, and tissue repair. MDK is pleiotropic and promotes angiogenesis, neurogenesis, chondrogenesis, cell growth, cell migration, and tumorigenesis. It also inhibits apoptosis in some cells. MDK acts through several different receptors including PTP, ALK, PTP-zeta, and LRP. MDK shows significant homology to pleiotrophin (PTN). The amino acid sequence of Rat MDK is 99% homologous to human MDK.

Neutral red dye is a dark brown to dark green power used to stain nuclei red, in cell viability tests, and as a pH indicator (transition of pH indicator: pH 6.8-8.0, red to yellow). Additionally, it is used to prepare neutral red paper and as a histological stain for lysozymes.

Platelet-derived growth factor (PDGF) is a glycoprotein present in serum but absent from plasma. PDGF has three subforms: PDGFAA, PDGFBB, and PDGF-AB. This form is a disulfide-linked homodimer consisting of two peptide chains A (PDGFAA). It is involved in a number of biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development. The function of PDGF is mediated by two tyrosine kinase receptors, PDGFR-α and PDGFR-β. PDGFR-α is the receptor that binds PDGFAA.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Rat PPBP is an ELR type of CXC chemokine. This recombinant protein is a mature, proteolytically processed form of PPBP that is also known as NAP2. It is expressed in monocytes and macrophages, especially from the lungs, after treatment with bacterial endotoxins and released from the alpha-granules of platelets after their activation. NAP2 is chemotactic for fibroblasts and neutrophils and binds to the receptor CXCR2. It is involved in a variety of cellular processes including mitogenesis, DNA synthesis, extracellular matrix synthesis, glycolysis, and plasminogen activator synthesis.

Rat Prolactin (PRL) is a peptide hormone that is secreted most notably from the pituitary gland where it acts in an endocrine fashion, but also from extra pituitary regions where it acts in an autocrine or paracrine fashion. It is listed as having over 300 separate functions and is involved in more processes than any other pituitary hormone. PRL is most commonly known for its lactation stimulating effect, but also plays a role in reproductive behavior, homeostasis of electrolytes, growth and development, regulation of metabolism, immune system regulation, angiogenesis, and survival of cancer cells. PRL acts as a ligand for the prolactin receptor, PRLR.

Rapamycin is a macrolide antibiotic isolated from Streptomyces hygroscopicus. It has been shown to display anticancer activity such as induction of apoptosis and inhibition of angiogenesis and proliferation in tumor cell lines. Rapamycin is also an immunosuppressant and FRAP inhibitor and inhibits lymphokine-induced cell proliferation.

Nonfluorescent resazurin, which is reduced by viable cells to red-fluorescent resorufin, can be used to detect the metabolic activity of many cell types from bacteria to higher eukaryotes and is a sensitive fluorogenic substrate for fluorometric and UV-spectrophotometric assays of phosphatases. Resazurin is used in the Resazurin Microtiter Assay for rapid detection of multidrug-resistant Mycobacterium tuberculosis, in cell viability tests, and to assay mitochondrial functions in vitro.

Resorufin-beta-D-galactopyranoside is a fluorogenic substrate for resorufin.

Resorufin-β-D- glucuronic acid is a fluorogenic substrate for β-glucuronidase, yielding resorufin upon cleavage.

Ribavirin is broad-spectrum antiviral nucleoside active against HIV, RSV, HCV, and adenovirus. It functions as a precursor to diphosphates and triphosphates, which inhibit viral RNA-dependent RNA polymerases. Ribavirin is an inhibitor of purine biosynthesis. Additionally, a metabolite of ribavirin, ribavirin 5’-phosphate, is an inhibitor of inosine monophosphate dehydrogenase.

Ribonolactone is a monosaccharide carbohydrate beta-lactone which can function as a reagent. In chiral acrylics, cyclopentenones and oxabicyclic systems, Ribonolactone is a building block. Research on the substance involves carbohydrate chemistry and photochemical synthesis. Ribonolactone has been identified as an effective analyte protectant for GC/MS analyzing pesticide. This metabolite which has been isolated in human biofluids when the individuals suffer from neuroblastoma.

Ribostamycin is an aminoglycoside antibiotic isolated from Streptomyces ribosifidicus. It is a broad-spectrum antibiotic targeting gram-positive and gram-negative bacteria. Ribostamycin has been used to in pharmacokinetic studies and to study kidney toxicity. It is also an inhibitor of protein disulfide isomerase (PDI).

Rifampicin is a broad-spectrum antibiotic known for its efficacy against tuberculosis and other infections caused by Mycobacterium species. This semisynthetic antibiotic has also been shown to work against methicillin-resistant Staphylococcus aureus (MRSA), to activate nuclear pregnane x receptor (PXR), and to promote CYP2C-mediated metabolism.

Rifampicin functions by binding the β-subunit of RNA polymerase, inhibiting RNA synthesis. Resistance to this antibiotic develops from mutations on the binding site on RNA polymerase leading to a lower affinity for rifampicin.

RNase A, isolated from bovine pancreas, degrades single-stranded RNA at the C and U residues; therefore, RNase A is pyrimidine specific. Degradation occurs by cleaving the phosphodiester bond located between the 5’-ribose of the nucleotide and the phosphate group that is connected to the 3’-ribose of the neighboring pyrimidine.

Ropivacaine is a local anaesthetic (amide caine) in which (S)-N-propylpipecolic acid and 2,6-dimethylaniline are combined to form the amide bond. Our ropivacaine is the S-enantiomer form of the compound with a purity of >98%.

Roxithromycin is a macrolide antibiotic and derivative of erythromycin. It targets both gram-negative and gram-positive bacteria and has shown strong efficacy against Legionella pneumophila and a variety of oral pathogens. Additionally, roxithromycin inhibits the activation of NADPH oxidase and promotes neutrophil apoptosis.

GoldBio’s RR1 chemically competent E. coli cells are suitable for high-efficiency transformation in a wide variety of applications such as cloning and sub-cloning. E. coli RR1 is a recA+ derivative of the HB101 strain and can be more useful than HB101 if a recA+ background is required.

Product Specifications
Competent cell type: Chemically competent
Derivative of: RR1
Species: E. coli
Format: Tubes
Transformation efficiency: ≥3 x 10⁷ cfu/µg pUC19 DNA
Blue/white screening: No

SAA1 is a positive acute phase apolipoprotein reactant that associates with HDL. It is expressed predominantly by hepatocytes in the liver and secreted into plasma, but is also expressed and secreted by adipocytes, endothelial cells, and peripheral monocytes. Expression of SAA1 is induced by LPS and by a variety of cytokines such as IL1, IL6, and TNF. Induction causes a dramatic increase of SAA1 levels in blood, indicating that it may play a short-term role in response to injury and inflammation. SAA1 can aggregate into insoluble fibrils that are deposited in various tissues or organs and disrupt normal function, a condition known as amyloidosis. Amyloidosis of SAA1 is associated with rheumatoid arthritis. SAA1 induces the synthesis of a variety of cytokines and proteinases and inhibits proliferation of endothelial cells. When not bound to HDL, it is chemotactic for monocytes, phagocytes, CD4(+) and CD8(+) T-cells, and polymorphonuclear leukocytes. SAA1 is a ligand for CD36/SR-B3, SR-B1, FPRL1, TLR2, and RAGE.

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!