Glycopeptides

Bleomycin A5 hydrochloride is a compound part of the glycopeptide antibiotic family. It is currently used in oncology research for its strong stimulatory and inhibitory effects. Bleomycin A5 greatly reduces telomerase activity, hindering the proliferation of malignant cells. It has also been shown to induce in vivo fibrosis and inflammation by generating peroxynitrites, a strong oxidizing agent.

Bleomycin A5 stimulates downstream apoptosis by increasing cysteine-aspartic acid protease-3 (caspase-3) activity, tumor protein 53 (p53) production and transforming growth factor beta 1 (TGF-beta 1) formation. These proteins induce apoptosis directly or indirectly by halting cell growth.

Bleomycin Sulfate is an anti-cancer agent isolated from Streptomyces verticillus. Bleomycin is a mixture of bleomycin A2 and bleomycin B2, in an approximately 2:1 ratio, respectively. However, the ratio varies by lot number.

Bleomycin is used against Hodgkin’s lymphoma. Its mechanism is not well understood; however, it is though that bleomycin chelates metallic ions causing a decrease in enzyme stability. The enzymes react with oxygen and produce free radicals, ultimately causing single-stranded breaks in deoxyribose sugars of DNA.

Teicoplanin is a glycopeptide antibiotic isolated from Actinoplanes teichomyceticus. It is a mixture of several teicoplanins. Teicoplanin is effective against gram-positive bacteria resistant to β-lactam antibiotics. It has been effective against methicillin-resistant Staphylococcus aureus and Enterococcus faecalis.

The vancomycin hydrochloride EZ Pak™ is the fastest and easiest way to make a set amount of sterile vancomycin hydrochloride solution. The kit includes pre-weighed vancomycin hydrochloride powder, a sterile filter, and a sterile container for the filtered solution. No need to calculate, simply add the stated amount of deionized H₂O, filter, and pour into the labeled bottle for easy usage. The EZ Pak™ includes high-quality GoldBio Vancomycin hydrochloride and the sterile solution is ready for tissue culture, bacterial media, or any number of uses.

Vancomycin hydrochloride is a member of the glycopeptide antibiotic class derived from Streptomyces orientalis. It is effective against gram-positive bacteria and used in studies of antibiotic resistance bacteria and nanoparticle transport studies. Exhibiting low toxicity to plants, vancomycin is suitable for plant selection and prevention of bacterial contamination in plant cell culture applications.