Carbapenems are a class of β-lactams with broad antibacterial activity. β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBPs are enzymes that catalyze a pentaglycine cross-link between alanine and lysine residues, providing additional strength to the cell wall. Without a pentaglycine cross-link, the integrity of the cell wall is severely compromised, and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Carbapenems are highly resistant to β-lactamases, and are commonly used as a last resort antibiotic of choice in the medical field due to their broad efficacy against both gram-positive and gram-negative bacteria and their poor oral bioavailabilility.
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|F-350-50||50 mg||$ 296.00|
Faropenem sodium is an ultra broad-spectrum β-lactam of the penem antibiotic class. It has been shown to be β-lactamase resistant and is especially effective against anaerobic bacteria responsible for oral infections, but targets a variety of gram-positive and gram-negative bacteria. Faropenem sodium is freely soluble in water.
|Grade||MOLECULAR BIOLOGY GRADE|
|M-820-10||10 g||$ 285.00|
Meropenem is a carbapenem β-lactam antibiotic. It targets gram-negative and gram-positive bacteria and displays high resistance to β-lactamase and kidney dehydropeptidase I activity. It is especially effective against bacteria responsible for causing meningitis and exhibits low toxicity when compared to similar antibiotics.
|Storage/Handling||Store desiccated at -20°C.|