Spermine is a polyamine derived from spermidine. It is involved in the cellular metabolism of all eukaryotic cells, as well as being vital to some bacteria.
Due to its polycationic nature, nonviral gene therapy applications involving spermine have shown promising results. This has had a positive impact in cancer research involving the lungs.
Gene transfer within the lungs is met with many obstacles due to inflammatory and immunological responses. Using spermine or using modified spermine as a gene delivery vehicle to transfect living cells has bypassed some of these obstacles, showing higher gene expression.
MW: 202.35 g/mol
Storage/Handling: Store desiccated at 4°C. Protect from light and air.
|Store desiccated at 4°C. Protect from light and air.