Levofloxacin is a fluoroquinolone antibiotic that is an optical S-(-) isomer of ofloxacin. In vitro susceptibility tests show a large degree of activity towards gram-positive and gram-negative bacteria with moderate anaerobic activity.
Fluoroquinolones are a group of broad-spectrum antibiotics that inhibit DNA synthesis. These antibiotics prevent unwinding of double-stranded DNA by binding DNA gyrase or DNA topoisomerase. By preventing the formation of single-stranded DNA, fluoroquinolones inhibit bacterial replication.
Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.
Formula: C18H20FN3O4 ∙ 0.5 H2O
MW: 379.39 g/mol
Storage/Handling: Store at 4°C.
PubChem Chemical ID: 149096
|Store at 4°C.