IL1RN (IL-1RA), Murine

Product Description

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Recombinant Murine Interleukin-1RN
Interleukin 1RN

Interleukin-1 receptor antagonist (IL1RN) was initially called the interleukin-1 (IL1) inhibitor, which is encoded by the IL1RN gene and is a member of the IL1 cytokine family. IL1RN is secreted by various types of cells, including immune cells, epithelial cells and adipocytes. In addition, IL1RN inhibits the activity of IL1 by binding to the receptor IL1R1 and preventing its association with the co-receptor IL1RAP for signaling. IL1RN is also used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL1 plays a key role. The murine IL1RN is a single nonglycosylated polypeptide chain containing 152 amino acids and has been shown to block the inflammatory responses induced by IL1 both in vitro and in vivo. The protein shows 26% amino acid homology to IL1B and 19% homology to IL1A. It also shares 90% amino acid sequence identity with rat IL1RN.

Sterile Filtered White Lyophilized Powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~17.3 kDa (152 amino acids)

Purity: >97% by SDS-PAGE and HPLC analyses.

Storage/Handling: Store desiccated at -20°C.


MGI: 96547

Cross-species Homology

Percent Similarity:

HuIL1RN *** 77.0 75.0
MuIL1RN *** *** 90.1
RtIL1RN *** *** ***

Additional resources for this protein may be found at:

Product Specifications

Catalog ID 1310-01C
MW ~17.3 kDa
Storage/Handling Store desiccated at -20°C.

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$12.99 Ground shipping (In continental US only.)

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