The cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.
Cyclosporin D is soluble in DMSO and ethyl alcohol.
MW: 1,216.64 g/mol
Storage/Handling: Store at 4°C.
PubChem CID: 6436250
|Storage/Handling||Store at 4°C.|