Apramycin is an aminoglycoside antibiotic useful against gram-negative bacteria such as E. coli and Salmonella species. It is used to study antibiotic resistance and protein synthesis translocation inhibition. Apramycin sulfate is freely soluble.
Aminoglycoside antibiotics are composed of amino groups attached to glycosides. They bind the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of translocation. Consequently, protein synthesis is inhibited.
Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.
MOLECULAR BIOLOGY GRADE
Formula: C21H41N5O11 • H2SO4
MW: 637.66 g/mol
Storage/Handling: Store at 4°C.
PubChem Chemical ID: 22008191
|Grade||MOLECULAR BIOLOGY GRADE|
|Storage/Handling||Store at 4°C.|