Five Tips To Make Your Research Antibiotics Last Longer
How do you make research antibiotics last longer? This is a common question in the lab, and research...
Cefotaxime is a third generation, broad-spectrum cephalosporin antibiotic effective against various gram-negative and gram-positive bacteria. However, unlike many other cephalosporins, cefotaxime is not effective against Pseudomonas aeruginosa bacteria. Cefotaxime is often used in Agrobacterium tumefaciens-mediated transformations to regulate bacterial growth. It has been shown to exhibit a synergistic effect with Vancomycin in certain conditions.
Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.
GoldBio’s antibiotic solutions are provided ready to use.
Product Specifications:
Cefotaxime Sodium in H2O
(100 mg/mL Premade Solution, 0.2 µm Sterile Filtered)
MOLECULAR BIOLOGY GRADE
Formula: NaC16H16N5O7S2
MW: 477.45 g/mol
Storage/Handling: Store at -20°C.
PubChem Chemical ID:
10695961
Catalog ID | C-104-SL |
---|---|
CAS # | 64485-93-4 |
MW | 477.45 g/mol |
Grade | MOLECULAR BIOLOGY GRADE |
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