Ceftriaxone Sodium, USP Grade

Ceftriaxone is a third generation cephalosporin antibiotic, which targets gram-negative and gram-positive bacteria. It has been used in proteomics research and to study prophylactic strategies to treat hemolytic anemia caused by prescription medications. In addition, ceftriaxone has been used to study the penicillin binding proteins, especially PBP1. It has been suggested that it also increases EAA2 pump expression in the central nervous system and decreases glutamatergic toxicity. It is freely soluble in aqueous solution.

Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Ceftriaxone Sodium, USP Grade
Ceftriaxone Disodium Salt Hemi(heptahydrate), USP Grade

Formula: C₁₈H₁₆N₈Na₂O₇S₃ ∙ 3.5 H₂O

MW: 661.60 g/mol

Storage/Handling: Store at 4°C.

PubChem CID: 124202479