Thiostrepton

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Product Description

Thiostrepton is a cyclic peptide antibiotic isolated from Streptomyces azureus. It targets a wide variety of gram-negative and gram-positive bacteria, especially those causing skin infections. It has been used as a marker for selection of recombinant Streptomyces cultures. Additionally, thiostrepton has been shown to inhibit FOXM1, a gene commonly overexpressed in cancer cell lines, thus inhibiting cancer cell growth.

Thiostrepton functions by binding elongation factor G (EF-G) and interfering with ribosomal GTPase activity, ultimately inhibiting protein synthesis.

Product Specifications
Thiostrepton

MOLECULAR BIOLOGY GRADE

Formula: C72H85N19O18S5

MW: 1,664.89 g/mol

Storage/Handling: Store at -20°C.
This product is soluble in acetic acid, chloroform, DMF, and DMSO.

PubChem Chemical ID: 16129666

Product Specifications

Catalog ID T-300
CAS # 1393-48-2
MW 1664.89 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at -20°C.

Technical Documentation

P Protocol
O Other
C Certificate of Analysis
S Safety Data Sheet

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