Description
Rifampicin is a broad-spectrum antibiotic known for its efficacy against tuberculosis and other infections caused by Mycobacterium species. This semisynthetic antibiotic has also been shown to work against methicillin-resistant Staphylococcus aureus (MRSA), to activate nuclear pregnane x receptor (PXR), and to promote CYP2C-mediated metabolism.
Rifampicin functions by binding the β-subunit of RNA polymerase, inhibiting RNA synthesis. Resistance to this antibiotic develops from mutations on the binding site on RNA polymerase leading to a lower affinity for rifampicin.
TESTED AGAINST BOTH SENSITIVE AND RESISTANT CELLS AT GOLD BIOTECHNOLOGY LABS.
Product Specifications
Rifampicin
RMP
Rifampin
Formula: C43H58N4O12
MW: 822.94 g/mol
Storage/Handling: Store desiccated at -20°C.
Soluble at 50 mg/ml in DMSO or up to 16 mg/ml in Methanol.
PubChem Chemical ID: 135398735
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