Puromycin Dihydrochloride

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Description

Puromycin is an aminonucleoside antibiotic that causes early chain termination within the ribosome during translation. This inhibition of translation is effective in both in vivo and in vitro applications, making it an ideal tool for protein synthesis studies. While selection for E. coli cells is possible with puromycin, it is more commonly and effectively used for mammalian cell selection.

The growth of bacteria, protozoa, algae and mammalian cells is quickly halted by puromycin. However, cells with the pac gene have resistance. Its gene product is puromycin-N-acetyl-transferase which inactivates puromycin through acetylation.

Research has shown puromycin to be effective against certain tumors.

Puromycin is soluble in water and is often used as a selective agent in molecular biology research.

Product Specifications
Puromycin Dihydrochloride

Formula: C22H29N7O5 • 2HCl

MW: 544.43 g/mol

Storage/Handling: Store desiccated at -20°C.

PubChem Chemical ID 443311

Puromycin Dihydrochloride

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Catalog Number:
P-600-100
CAS Number:
58-58-2
$116.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
In stock
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Puromycin is an aminonucleoside antibiotic that causes early chain termination within the ribosome during translation. This inhibition of translation is effective in both in vivo and in vitro applications, making it an ideal tool for protein synthesis studies. While selection for E. coli cells is possible with puromycin, it is more commonly and effectively used for mammalian cell selection.

    The growth of bacteria, protozoa, algae and mammalian cells is quickly halted by puromycin. However, cells with the pac gene have resistance. Its gene product is puromycin-N-acetyl-transferase which inactivates puromycin through acetylation.

    Research has shown puromycin to be effective against certain tumors.

    Puromycin is soluble in water and is often used as a selective agent in molecular biology research.

    Product Specifications
    Puromycin Dihydrochloride

    Formula: C22H29N7O5 • 2HCl

    MW: 544.43 g/mol

    Storage/Handling: Store desiccated at -20°C.

    PubChem Chemical ID 443311

    Product Specifications

    Catalog ID: P-600
    CAS #: 58-58-2
    Formula: C22H29N7O5•2HCl
    MW: 544.43 g/mol
    Storage/handling: Store desiccated at -20°C.

    CITATIONS

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