PTH (1-84), Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Parathyroid Hormone (PTH)
Parathyrin
Parathormone
Parathyroid Hormone 1 (PTH1)

Human Parathyroid Hormone (PTH) is a hormone expressed and secreted as preproPTH by chief cells of the parathyroid glands when extracellular calcium levels are low. It is coexpressed with furin, the enzyme believed to be responsible for processing proPTH to PTH. PTH is a ligand for two different receptors, PTH1R in bone and kidney and PTH2R found in the CNS, pancreas, and placenta. PTH plays a major role in bone metabolism and calcium homeostasis, as well as renal excretion. In osteoblasts, PTH stimulates glycogenesis and the uptake of [1-(14)C]-2-deoxy-D-glucose (2DG).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~9.4 kDa (84 amino acids)

Purity: >97% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The ED₅₀ as determined by its ability to induce cAMP accumulation in murine MC3T3E1 cells is less than 50 ng/ml, corresponding to a specific activity of >2.0×10⁴ IU/mg.

Storage/Handling: Store desiccated at -20°C.

HGNC: 9606

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM