Nystatin is a fungicidal and fungistatic polyene antifungal targeting Candida species, especially those responsible for vaginal infections. It functions by inhibiting ergosterol synthesis and increasing cell membrane permeability, ultimately leading to fungal cell death. Nystatin has been used in combination with erythromycin and streptomycin in cell culture to eliminate fungal contamination.
Nystatin is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.
MOLECULAR BIOLOGY GRADE
MW: 926.09 g/mol
Lot Specific Potency:
Lot 1028 - 6410 units/mg
Storage/Handling: Store at -20°C.
Store under inert gas. This product is light sensitive, and is freely soluble in DMF and DMSO.
PubChem Chemical ID: 71308475
|MOLECULAR BIOLOGY GRADE
|Store at -20°C.
Antibiotic Treatments of Microbe-Contaminated Cell Cultures
Procedure on the use of different antibiotics to eliminate fungal, bacterial and mycoplasma contamination of cell lines
Sample COA - N-750
Sample Certificate of Analysis - Nystatin
COA for example only. Actual tests may differ.