IL17A, Rat

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Rat Interleukin 17A
IL17, IL17A
Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 (CTLA8)

Rat Interleukin 17A (IL17A) belongs to the IL17 family that contains IL17A, IL17B, IL17C, IL17D, IL17E and IL17F. All of the members of the IL17 family are proinflammatory cytokines that share four conserved cysteine residues, but diverge at the N-terminus. Both recombinant and natural IL17 have been shown to exist as disulfide linked homodimers, and mature IL17 contains one potential N-linked glycosylation site. IL17 is a T-cell expressed pleiotropic cytokine that regulates the activities of NF-kappaB and mitogen-activated protein kinases, and can stimulate the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~30.0 kDa (homodimer of two 133 amino acid chains)

Purity: >95% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The ED₅₀ as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 1.0 ng/ml, corresponding to a specific activity of >1.0×10⁶ IU/mg.

Storage/Handling: Store desiccated at -20°C.

RGD: 2888

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM