IFN-lambda3 (IL28B), Murine
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Recombinant Murine Interferon Lambda 3
Interleukin 28B (IL28B)
Interferon lambda 3, also known as interleukin 28B, belongs to the newly classified type III interferon family. Expression of IFNL3 is seen in a variety of cell types in response to viral infection or treatment with double-stranded RNA. IFNL3 exerts antiviral activity and up regulation of MHC class I antigen expression. It also plays a role in Toll-like receptor (TLR)-induced antiviral defense. IFNL3 signals through a heterodimeric receptor complex composed of IL10RB and IFNLR1 which activates the JAK-STAT pathway, phosphorylating STAT1, STAT2, and STAT3. In individuals with chronic hepatitis C, the presence of specific polymorphisms near this gene has been associated with an increased response in treatment for the condition with interferon and ribavirin.
Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.
Source: Escherichia coli
MW: ~19.6 kDa (174 amino acids)
Purity: >98% by SDS-PAGE and HPLC analyses
Biological Activity: Fully biologically active when compared to standard. The ED 50 as determined by an anti-viral assay using human HepG2 cells infected with encephalomyocarditis is less than 30 ng/ml, corresponding to a specific activity of >3.3×104 IU/mg.
Storage/Handling: Store desiccated at -20°C.
Mouse Genome Database ID: 2450574
NOT FOR HUMAN USE!
Additional resources for this protein may be found at:
|Store desiccated at -20°C.