DEFB105A, Human

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Product Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Defensin, Beta 105A
Defensin, Beta 5, DEFB5, hBD-5

Human beta-defensin 105A (DEFB105A) is an antimicrobial peptide that contributes to both the innate and the adaptive immune systems and is active against gram-negative and gram-positive bacteria, fungi, and viruses. Like the other β-defensins, DEFB105A is a small protein that contains a motif consisting of six cysteine residues which form three intramolecular disulfide bridges. It is expressed in the testis and epididymis. DEFB105A is a cationic peptide and interacts with the membranes of invading microbes, which are negatively charged due to the presence of lipopolysaccharides (LPS) or lipoteichoic acid (LTA). LTA and LPS have higher affinity for DEFB103A than for Ca+2 and Mg+2 ions. The larger defensin molecule displaces the smaller ion, changing the membrane structure and affecting the stability of the membrane; this can lead to the formation of pores and subsequent depolarization or lysis. DEFB105A differs from the other β-defensins by consisting of 3 exons and 2 introns, instead of 2 exons and 1 intron.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~5.8 kDa (51 amino acids)

Purity: >95% by SDS-PAGE and HPLC analyses.

Storage/Handling: Store desiccated at -20°C.

HGNC: 18087

NOT FOR HUMAN USE!


Product Specifications

Catalog ID 1190-05
MW ~5.8 kDa
Storage/Handling Store desiccated at -20°C.

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