CXCL12-alpha, Rat

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Product Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Rat Chemokine (C-X-C motif) Ligand 12, Alpha (CXCL12α)
Stromal Cell-Derived Factor 1 (SDF1)
Small Inducible Cytokine Subfamily B Member 12 (SCYB12)
Pre-B Cell Growth-Stimulating Factor (PBSF)
Thymic Lymphoma Cell-Stimulating Factor (TLSF)

Rat CXCL12 is a CXC chemokine lacking the ELR motif. It was first found in bone marrow stromal cells and is expressed in bone marrow stromal cells constitutively as well as a wide variety of cells with the exception of blood cells. Expression of CXCL12 is downregulated in fibroblasts by the phorbol ester TPA and in serum-deprived fibroblasts that have been stimulated by serum. CXCL12 acts as a ligand for CXCR4 and CXCR7. It is chemotactic for hematopoietic progenitor cells expressing CD34, mononuclear cells, and cerebellar granule cells. CXCL12 plays a role in lymphopoiesis, myelopoiesis, vascularization of the gastrointestinal tract, and cerebellar development. CXCL12-alpha is one of six alternatively spliced isoforms of the CXCL12 gene. It is four amino acids shorter at the C-terminus than the canonical sequence, CXCL12-beta.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~7.9 kDa (68 amino acids)

Purity: >97% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 50-100 ng/ml.

Storage/Handling: Store desiccated at -20°C.

RGD: 3651


Additional resources for this protein may be found at:

Product Specifications

Catalog ID 2510-12A
MW ~7.9 kDa
Storage/Handling Store desiccated at -20°C.

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