Clotrimazole is an antifungal that targets the cell membrane of a variety of fungi including Candida and Aspergillus. It inhibits the synthesis of ergosterol causing an increase in cell membrane permeability. Additionally, clotrimazole is an activator of MB67 and inhibitor of CYP3A4 and CYP51A1.
Clotrimazole is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.
MOLECULAR BIOLOGY GRADE
MW: 344.84 g/mol
Storage/Handling: Store at 2-8°C. Protect from light. Clotrimazole is soluble in acetone, alcohol, chloroform, DMF, and ethyl acetate.
PubChem Chemical ID: 2812
|Grade||MOLECULAR BIOLOGY GRADE|
|Storage/Handling||Store at 4°C. Protect from light.|