Clindamycin is a lincosamide antibiotic primarily targeting gram-positive bacteria. It is also against anaerobic bacteria and protozoans such as Toxoplasma species.
Clindamycin binds the 50s ribosomal subunit preventing ribosomal translocation, resulting in inhibition of protein synthesis. It has been shown to exhibit synergistic properties when combined with vancomycin.
Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.
MOLECULAR BIOLOGY GRADE
Formula: C 18H33ClN2O5S·HCl
MW: 461.44 g/mol
Storage/Handling: Store desiccated at -20°C. Soluble in water.
PubChem Chemical ID 16051951
|Grade||MOLECULAR BIOLOGY GRADE|
|Storage/Handling||Store desiccated at -20°C.|
Broth Microdilution and Disk Diffusion
Broth Microdilution & Disk Diffusion tests of Erythromycin and Clindamycin by Jorgensen et. al. (2011)
Sample COA - C-175
Sample Certificate of Analysis - Clindamycin Hydrochloride
COA for example only. Actual tests may differ.