Description
Cefepime is a fourth generation cephalosporin antibiotic effective against gram-negative and gram-positive bacteria. It is resistant to a variety of β-lactamases, and is effective against some naturally resistant bacterial species such as Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. Cefepime is slightly soluble in aqueous solution.
Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.
Product Specifications
Cefepime
MOLECULAR BIOLOGY GRADE
Formula: C19H24N6O5S2
MW: 480.56 g/mol
Storage/Handling: Store at 2-8 °C.
PubChem Chemical ID: 5479537
