Cecropin B is a 35 amino acid chain that functions as an antibacterial and anti-cancer peptide. It is characterized by two alpha helices and has been researched because of the low cytotoxicity produced. Cecropin B has been shown to produce in vivo cytotoxic effects against stomach carcinomas. It has also been used to synthesize derivatives with activity against other cancer cell lines.
Cecropin B has been shown to cause bacterial and cancerous cell death by insertion into the cellular membrane, which is due to amphiphilic N-terminal residues. In low lipid to peptide membrane component ratios, cecropin B will form ion channels that will disrupt metabolic gradients and lead to cell death. With high membrane peptide concentrations, cecropin B was observed to aggregate membrane peptides and break the membrane into fragments.
MW: 3.84 kDa
Storage/Handling: Store desiccated at -20°C.
PubChem Chemical ID: 16130488