Caffeic acid phenethyl ester

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Product Description

Caffeic acid phenethyl ester (CAPE) is the active component of propolis, a honeybee hive product. Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor, NF-κB. CAPE has been shown to significantly suppress the Lipoxygenase pathway of arachidonic acid metabolism during inflammation. Caffeic acid phenethyl ester inhibits HIV-1 integrase, and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and Ornithine Decarboxylase activity.


Product Specifications

Caffeic acid phenethyl ester
Phenethyl 3,4-Dihydroxycinnamate; CAPE

MOLECULAR BIOLOGY GRADE

Formula: C 17H16O4

MW: 284.310 g/mol

Slightly off-white to yellowish crystalline powder

Storage/Handling: Store desiccated at -20°C. Protect from light.

PubChem ID:5281787

References:
1. Grunberger, D. et al. Preferential cytotoxicity on tumor cells by caffeic acid pheethyl ester isolated from propo lis. Experienta 1988, 44, 230-232 2.
2. Fesen, M.R., et al., In hibitors of human immunodeficiency virus integrase. Proc . Natl. Acad. Sci. USA 1993, 90, 2399-2403 3.
3. SudÕina, G.F., et al., Caffeic acid phenetyl ester as a lipoxygenase inhib itor with antioxidant properties. FEBS Lett. 1993, 329, 21-24 4.
4. Fesen M.R., et al., Inhibitiion of HIV-1-integrase by flavones, caffeic acid phenethyl ester (CAPE) and rel ated compounds. Biochem. Pharmacol. 1994, 48, 595-608 5.
5. Zhe ng, Z.S., et al., Caffeic acid phenetyhl ester inhibits prol iferation of human keratinocytes and interferes with the EGF regualton of ornithine decarboxylase. Oncol. Res. 1995, 7, 445-452 6.
6. Mirzoeva, O.K., and Calder, P.C., The effect of propolis and its components on eicosanoid production duri ng inflammatory response. Prostaglandins Leukot. Essent. Fatty Acides 1996, 55, 441-449 7.
7. Natarajan, K. et al., Caf feic acid phenethyl ester as a potetnt and specific inhibito r of activation of nuclear transcription factor NF-kappa B. Proc. Natl. Acad. Sci. USA 1996, 93, 9090 - 9095

Product Specifications

Catalog ID C-070
CAS # 104594-70-9
MW 284.31 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store desiccated at -20°C. Protect from light.

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