Aztreonam, Solubilized

Aztreonam solubilized is blend of aztreonam and 42-45% L-Arginine, making the product freely soluble in water. Aztreonam is a monobactam β-lactam antibiotic whose structure contains only a single ring. Its unique ring structure makes it resistant to β-lactamases. Aztreonam is effective against gram-negative bacteria and is an economical antibiotic commonly used in plant tissue culture applications and against P. aeruginosa.

β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Resistance to β-lactam antibiotics occurs in the presence of cells containing plasmid encoded extended spectrum β-lactamases or ESBLs.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Aztreonam

MOLECULAR BIOLOGY GRADE

Formula: C₁₃H₁₇N₅O₈S₂

MW: 435.43 g/mol (active ingredient)

Storage/Handling: Store at 2-8 °C.

PubChem CID: 5742832