CCL11, Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Chemokine (C-C motif) Ligand 11 (CCL11)
Eotaxin, Eotaxin 1
Small Inducible Cytokine Subfamily A Member 11 (SCYA11)

CCL11 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed in dermal fibroblasts. Expression of CCL11 is induced by IL1A and TNFA and inhibited by IFNG. It is strongly and selectively chemotactic for eosinophils and induces a calcium flux response in eosinophils; thus it is involved in a variety of eosinophilic inflammatory diseases. CCL11 is a ligand for CCR1, CCR2, CCR3, CCR5, and ACKR2 (D6).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~8.4 kDa (74 amino acids)

Purity: >97% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration of 0.1-10 ng/ml.

Storage/Handling: Store desiccated at -20°C.

HGNC: 10610

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM