6-Dimethylamino-9-(b-D-ribofuranosyl)purine is a methyladenosine compound functioning as a heterocyclic building block and reagent in nucleotide chemistry. It’s composed of two methyl groups bound to an adenine nucleobase. 6-Dimethylamino-9-(b-D-ribofuranosyl)purine has roles in nucleic composition. Modified with fatty acids, the molecule has been shown to be effective against tumor activity in cultured L1210 leukemia and Ehrlich ascites.
The tertiary amino compound is a minor rRNA nucleoside responsible for structure. Antibodies to 6-Dimethylamino-9-(b-D-ribofuranosyl)purine located the nucleoside in bacterial ribosomes, placing it at the 30S subunit of E. coli near the 3’ end; it is not present in kasugamycon-resistant mutants. In peas, chromatographic tests confirmed conservation in chloroplast rRNA subunits analogous to those in E. coli. Residues of this substance were likewise present in wheat germ at the small 18S and 40S RNA subunit particles. It’s been located in the tRNA of Mycobacterium bovis Bacille Calmette-Guérin (BCG) as well.
6-Dimethylamino-9-(b-D-ribofuranosyl)purine has demonstrated an inhibitory effect on Caco-2 cell apoptosis, suggesting the possibility of selection against malignant cells in cancer treatment. The carcinogen L-ethionine is capable of eliminating the production of 6-Dimethylamino-9-(b-D-ribofuranosyl)purine in liver tissue by selectively inhibiting the RNA-methylase which produces the adenosine component.
PubChem Chemical ID: