Cyclosporin D

The cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.

Cyclosporin D is soluble in DMSO and ethyl alcohol.

Product Specifications
Cyclosporin D

Formula: C₆₃H₁₁₃N₁₁O₁₂

MW: 1,216.64 g/mol

Storage/Handling: Store at 4°C.

PubChem CID: 6436250