Sulfadoxine (Sulphadoxine)

Sulfadoxine is a broad-spectrum sulfonamide antibiotic effective against gram-negative and gram-positive bacteria. It is commonly used against malaria, especially Plasmodium falciparum malaria with chloroquine resistance. It has been used to study Toxoplasma gondii infections and to prevent infections in post-surgical animal models.

Sulfonamide antibiotics are derived from a chemical called sulfanilamide. They function through inhibiting the conversion of p-aminobenzoic acid to dihydropteroate, an essential step in the synthesis of folic acid. By preventing the production of folate in bacteria, the sulfonamide antibiotics ultimately suppress bacterial DNA replication.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Sulfadoxine
Sulphadoxine

MOLECULAR BIOLOGY GRADE

Formula: C₁₂H₁₄N₄O₄S

MW: 310.33 g/mol

Storage/Handling: Store at -20°C.

PubChem Chemical ID: 17134