2-Deoxy-D-glucose is a molecule with a broad range of applications, from a reagent to a potential anti-cancer drug. As a reagent it can be combined with the radiolabel fluorine-18 to monitor glucose metabolism using positron emission tomography (PET) allowing detection of altered metabolism resulting from diseases like Alzheimer’s and cardiovascular disease. As a therapeutic drug 2-Deoxy-D-glucose uptake is the same as regular glucose, but has an inhibiting effect on cell growth. This makes it an effective tumor suppressant. It is a potential anti-epileptic drug due to its mimicry of ketogenic diets used for treating epilepsy, by increasing Brain-derived neurotrophic factors, nerve and basic fibroblast growth factors and Arc protein. 2-Deoxy-D-glucose’s anti-cancer properties stem from its ability to slow both tumor growth and mark tissues with elevated glucose and hexokinase activity, which are common markers for cancer activity. It can also be used to increase the absorption of other chemotherapy agents like adriamycin and paclitaxel.
MW: 164.16 g/mol
Storage/Handling: Store desiccated at -20°C.
PubChem Chemical ID: 439268
|Store at room temperature.