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Product Description

Hydroxyurea is a compound used in anti-cancer research to inhibit DNA synthesis and in sickle cell research for ways to alleviate symptoms. It has been shown to be a potent inhibitor of ribonucleotide reductase which reduces ribonucleotides to deoxyribonucleotides.

In vivo research has shown hydroxyurea converting into a free radical nitric oxide which binds the active site of ribonucleotide reductase, ceasing further DNA synthesis. The mechanism of nitric oxide release from hydroxyurea is not well understood.

Hydroxyurea has also been shown to alleviate sickle cell anemia through its conversion to nitric oxide in vivo. Nitric oxide alleviates endogenous nitric oxide loss, caused by hemolysis, and stimulates soluble guanylate cyclase (sGC) activity which will signal fetal hemoglobin production.

Product Specifications

Formula: CH­4N2O2

MW: 76.05 g/mol

Storage/Handling: Store desiccated at 4°C.

PubChem Chemical ID: 3657


Product Specifications

Catalog ID H-510
CAS # 127-07-1
MW 76.05 g/mol

Technical Documentation

P Protocol
O Other
C Certificate of Analysis
S Safety Data Sheet

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