Dihydrotanshinone I

Dihydrotanshinone I is a compound extracted from the plant Salvie miltorrhiza Bunge. It is used as a gram positive antibacterial and anti-cancer compound. In both in vivo and in vitro research, dihydrotanshinone I generated reactive oxygen species which trigger apoptosis in bacteria and cancer cells.

Dihydrotanshinone I triggers apoptosis by directly damaging DNA and preventing further replication or by activating p38 mitogen-activated protein kinases (p38 MAPK). This class of protein kinase engages apoptosis by activating caspases which are proteases that induce cell death. Dihydrotanshinone I has also been shown to inhibit cell growth past the G1 stage and prevent blood vessel formation by inhibiting hypoxia-inducible factor (HIF-1) activity.

Product Specifications
Dihydrotanshinone I
Tanshinone I, dihydro

Formula: C₁₈H₁₄O₃

MW: 278.30 g/mol

Storage/Handling: Store desiccated at 4°C.

PubChem Chemical ID: 11425923

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