Camptothecin (Camptotheca acuminata)

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Product Description

Camptothecin is an alkaloid compound used as an anti-cancer agent. It is a topoisomerase I inhibitor in DNA synthesis. Camptothecin has been shown to bind and stabilize a topoisomerase I-DNA complex in vitro, preventing the enzyme from reannealing DNA strands. This inhibition specifically effects the S-phase of cell development and ultimately results in apoptosis due to damaged DNA.

Camptothecin is produced by endosymbiotic fungi, from the division Ascomycota (Phycomycete), that are present in the tree Camptotheca acuminata which is native to southern China. Camptothecin (Mappia foetida), (GoldBio Catalog # C-565) has also been isolated from fungi on Mappia foetida (Nothapodytes foetida), a plant common to India.

Product Specifications
Camptothecin (Camptotheca acuminata)

Formula: C20H16N2O4

MW: 348.65 g/mol

Storage/Handling: Store desiccated at 4°C.

PubChem Chemical ID: 24360

Product Specifications

Catalog ID C-705
CAS # 7689-03-4
MW 348.65 g/mol
Storage/Handling Store desiccated at 4°C.

Technical Documentation

P Protocol
O Other
C Certificate of Analysis
S Safety Data Sheet

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