n-Dodecyl-B-D-maltoside (DDM)

Product Description

n-Dodecyl-B-D-Maltoside, or DDM, is a maltoside based non-ionic detergent with a hydrophilic maltose head and a hydrophobic long chain alkyl tail. It is considered a gentle detergent that is more efficient than other detergents, such as CHAPS or NP-40. It has a comparatively low critical micelle concentration (CMC) of 0.17mM compared to the other maltoside based detergents.

The primary attribute of DDM is its capability to extract hydrophobic proteins while maintaining the solution-phase protein conformation. DDM also allows the protein to be reformed following denaturation. Most membrane-bound proteins are α-helix bundles, which are less robust to changes in their cellular environment. DDM offers a detergent capable of preserving these proteins. This is in contrast to other, harsher ionic detergents that destabilize and permanently denature α-helical membrane-bound proteins. DDM has been used to solubilize the multidrug-transporter protein, EmrE, as well as the nucleoside-specific porin protein, Tsx.

DDM has also been shown in several cases to facilitate a high degree of reactivation of previously denatured enzymes, possibly due to weak bonding between DDM and intermediate conformational isomers.

Product Specifications
Dodecyl 4-O-α-D-glucopyranosyl-β-D-glucopyranoside;
Lauryl Maltoside

Formula: C­24H­­­46O11

MW: 510.63 g/mol

Storage/Handling:Store at -15oC. Protect from light

PubChem Chemical ID:114880

Product Specifications

Catalog ID DDM
CAS # 69227-93-6
MW 510.63 g/mol
Storage/Handling Store at -20°C. Protect from light.

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