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Ketoconazole is a broad-spectrum imidazole antifungal effective against a variety of fungal species including Candida species, Blastomyces species, and Histoplasma species. Ketoconazole functions by inhibiting ergosterol synthesis and increasing fungal cell membrane permeability. It is also a CYP3A4 inhibitor used to identify p-glycoprotein/CYP3A-limited bioavailability and to study interleukin 1 chemotherapeutic effects. It has also been used to study drug interactions and to inhibit synthesis of aldosterone, cortisol, and testosterone.
Ketoconazole is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.
MW: 531.43 g/mol
Storage/Handling: Store at 4°C.
This product is soluble in methanol and methylene chloride.
PubChem Chemical ID: 456201
|Store at 4°C.
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