Pipemidic acid is a pyridopyrimidine antibiotic with similar properties to quinolone antibiotics. It is used to study damage and mutations in DNA as well as lymphocyte blastogenesis and interferon-gamma production. It can be used as a cell selection agent.
Similarly to the fluoroquinolones, pipemidic acid inhibits DNA synthesis. It prevent unwinding of double-stranded DNA by binding DNA gyrase or DNA topoisomerase. By preventing the formation of single-stranded DNA, pipemidic acid inhibits bacterial replication.
Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.
MOLECULAR BIOLOGY GRADE
MW: 303.32 g/mol
Storage/Handling: Store at 4°C.
PubChem Chemical ID: 4831
|Grade||MOLECULAR BIOLOGY GRADE|
|Storage/Handling||Store at 4°C.|