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Adding a protease inhibitor to your cell suspensions will prevent unwanted proteolysis during protein extraction. Gold Biotechnology provides a broad selection of protease inhibitors that are specific for your research needs. These reversible and irreversible inhibitors are active against a variety of cysteine and serine proteases, and are effective in protecting proteins during extractions." 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Proteins are fundamental macromolecules found in every biological system and form the basis of many fields of work from research into drug creation to industrial applications like fermentation. GoldBio protein products are ideal for every step of your protein synthesis. Our reagents and tools are of the highest quality available at a fraction of the prices of other vendors, so you can be assured that your research yields confident results without compromising your budget.

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object(anvilstl\commercio\models\Category)#446 (15) { ["featured_image_urls"]=> array(3) { ["small"]=> string(90) "https://s3.amazonaws.com/commercio/goldbio-2018/collection/small/Antibiotics-Selection.jpg" ["medium"]=> string(91) "https://s3.amazonaws.com/commercio/goldbio-2018/collection/medium/Antibiotics-Selection.jpg" ["large"]=> string(90) "https://s3.amazonaws.com/commercio/goldbio-2018/collection/large/Antibiotics-Selection.jpg" } ["featured_image"]=> array(3) { ["small"]=> string(90) "https://s3.amazonaws.com/commercio/goldbio-2018/collection/small/Antibiotics-Selection.jpg" ["medium"]=> string(91) "https://s3.amazonaws.com/commercio/goldbio-2018/collection/medium/Antibiotics-Selection.jpg" ["large"]=> string(90) "https://s3.amazonaws.com/commercio/goldbio-2018/collection/large/Antibiotics-Selection.jpg" } ["banner_image_urls"]=> array(0) { } ["productCount"]=> NULL ["_attributes":"yii\db\BaseActiveRecord":private]=> array(23) { ["id"]=> int(300) ["root"]=> int(393) ["lft"]=> int(32) ["rgt"]=> int(33) ["level"]=> int(1) ["name"]=> string(29) "Antibiotics & Selection (old)" ["url_name"]=> string(26) "antibiotics-and-selection2" ["title"]=> NULL ["short_description"]=> string(0) "" ["long_description"]=> string(410) "

Antibiotics and Selection tools allow you to selectively control which cells can be found in your cultures.

GoldBio’s broad range of cell selection tools, including hundreds of antibiotics, antifungals and anticancers, plant selection and screening agents allow you to select, control and maintain your cell cultures with confidence and ease, no matter what cells you may be studying.

Antibiotics and Selection tools allow you to selectively control which cells can be found in your cultures.

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Carfilzomib

Name: Carfilzomib
SKU: C-915
Availability: InStock

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Product Description

Carfilzomib is a second generation proteasome inhibitor that has been used in oncology research.Being a derivative of epoxomicin, carfilzomib has a tetrapeptide epoxyketone structure.

The anti-cancer activity of carfilzomib on proteasomes is attributed to irreversibly binding to a 20S subunit on proteasomes. Affinity of carfilzomib for the subunit has been shown to be fairly significant, allowing carfilzomib to be effective at targeting multiple myeloma and lymphoma.

Proteasomes degrade excess or damaged proteins in both the nucleus and cytosol by cleaving hydrophobic residue peptide bonds. When proteasomes are inhibited by carfilzomib, polyubiquinated proteins accumulate. Polyubiquinated proteins will upregulate p21 synthesis, which activates cell cycle arrest and eventually apoptosis.

Carfilzomib has also been shown to have poor solubility in aqueous solutions, but greater solubility in organic solvents such as DMSO. Aqueous solubility can be enhanced by diluting carfilzomib-organic solvent solution in aqueous buffers. Using aqueous carfilzomib in biological settings should be done in dilute concentrations to limit organic solvent presence. Because carfilzomib organic-aqueous solutions only have a shelf life of approximately 24 hours, it is recommended to make small portions for immediate use.

Product Specifications
Carfilzomib
CFZ

Formula: C₄₀H₅₃N₅O₇

MW: 719.91 g/mol

Storage/Handling: Store at 4°C.
Soluble in DMSO.

PubChem Chemical ID: 11556711

Product Specifications

Catalog ID	C-915
CAS #	868540-17-4
MW	719.91 g/mol
Storage/Handling	Store at 4°C.

Technical Documentation

P Protocol

O Other

C Certificate of Analysis

S Safety Data Sheet

SDS (MSDS) - Carfilzomib

Safety Data Sheet

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