Product Description

AEBSF is an irreversible serine protease inhibitor. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin, kallikrein and thrombin. It inhibits by acylation of the active site of the enzyme. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25mM. Aqueous solutions are stable between pH 5-6; limited stability above pH 7.5.

Attention Canadian and Mexican customers: This product is a hazardous and can only ship via Air.


  • Serine Protease inhibitor
  • SREBP protein activation
  • PMSF/DFP alternative

Storage and Handling

Store at -20°C. Protect from light.

Working Concentration

Make stock solutions at 100mM. Aliquot and store at -20°C for up to 2 months.
AEBSF working concentrations are usually between 0.1-1.0mM and should be made daily.

Product Specifications

Catalog ID A-540
Name(s) AEBSF·HCl;
Pefabloc SC;
4-(2-Aminoethyl)-benzenesulfonylfluoride hydrochloride
CAS # 30827-99-7
Formula C8H10FNO2S · HCl
MW 239.69 g/mol
PubChem Chemical ID 186136
Storage/Handling Store at -20°C. Protect from light.

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$12.99 Ground shipping (In continental US only.)

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