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Showing 81-84 of 84 items.

NRG1-beta2, Human

Catalog ID Size Pricing
1170-10-10 10 μg $ 101.00
1170-10-100 100 μg $ 318.00
1170-10-500 500 μg $ 679.00

Description

Neuregulin 1 belongs to a family of structurally related polypeptide growth factors and is produced in numerous isoforms by alternative splicing, which allows it to perform a wide variety of functions. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They all have the EGF-like domain, and can bind to ErbB3 and ErbB4 receptor tyrosine kinases. This binding induces ErbB3 and ErbB4 heterodimerization with ErbB2, stimulating intrinsic kinase activity. This recombinant protein is the EGF-like domain of isoform 7. NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells. NRG1 is necessary for development, structural maintenance, and functional integrity of the heart. It is also thought to play a role in synaptic plasticity. Dysregulation of NRG1 has been linked to various cancers and schizophrenia.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Product Specifications

Catalog ID 1170-10
MW ~7.0 kDa
Storage/Handling Store desiccated at -20°C.
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1170-10-10 10 μg $ 101.00
1170-10-100 100 μg $ 318.00
1170-10-500 500 μg $ 679.00

NRN1, Human

There is no image for NRN1, Human NRN1, Human
Catalog ID Size Pricing
1170-22-5 5 μg $ 101.00

Description

Neuritin (NRN1) is a GPI-anchored neurotrophic factor, which is expressed in response to induction of neuronal activity by GDNF, BDNF, NT3 and other neural stimulators. It promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. NRN1 also promotes angiogenesis. During early brain development, NRN1 inhibits apoptosis of cortical progenitors by preventing activation of caspase 3. Recombinant human neuritin is a covalently disulfide-linked homodimer, consisting of two 9.7 kDa polypeptide monomers, each containing 88 amino acid residues.

Product Specifications

Catalog ID 1170-22
MW ~19.4 kDa
Storage/Handling Store desiccated at -20°C.
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1170-22-5 5 μg $ 101.00

NTF4, Human

Catalog ID Size Pricing
1170-04-10 10 μg $ 149.00
1170-04-100 100 μg $ 1,188.00
1170-04-500 500 μg $ 2,295.00

Description

Neurotrophin 4 (NTF4), also known as NT5, is a member of the NGF family of neuronal and epithelial growth factors. Neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds. Human NT4 shares 48 - 52% amino acid sequence identity with human β-NGF, BDNF and NT3. It shares 91% and 95% amino acid sequence identity with mouse and rat NT4/5, respectively. The protein is secreted as a homodimer and can also form heterodimers with BDNF or NT3. NT4 binds and induces receptor dimerization and activation of TrkB and promotes the development and survival of selected peripheral and CNS neurons. NT4 induced TrkB signaling augments NMDA receptor activity and increases neuronal sensitivity to excitotoxic cell death. NT4 is secreted by activated T cells and granulocytes and contributes to tissue regeneration at inflammation sites.

Product Specifications

Catalog ID 1170-04
MW ~28.0 kDa
Storage/Handling Store desiccated at -20°C.
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1170-04-10 10 μg $ 149.00
1170-04-100 100 μg $ 1,188.00
1170-04-500 500 μg $ 2,295.00

Nystatin

Catalog ID Size Pricing
N-750-10 10 g $ 66.00
N-750-25 25 g $ 124.00
N-750-50 50 g $ 165.00
N-750-100 100 g $ 231.00
N-750-250 250 g $ 388.00

Description

Nystatin is a fungicidal and fungistatic polyene antifungal targeting Candida species, especially those responsible for vaginal infections. It functions by inhibiting ergosterol synthesis and increasing cell membrane permeability, ultimately leading to fungal cell death. Nystatin has been used in combination with erythromycin and streptomycin in cell culture to eliminate fungal contamination.

Product Specifications

Catalog ID N-750
CAS # 1400-61-9
MW 926.09 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at -20°C.
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N-750-10 10 g $ 66.00
N-750-25 25 g $ 124.00
N-750-50 50 g $ 165.00
N-750-100 100 g $ 231.00
N-750-250 250 g $ 388.00

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