Lymphoid/Lymphocyte

Growth factors are expressed in in every system of the body, including that of the lymphoid/lymphocyte immune system. A key cytokine involved in that process is the tumor necrosis factor (TNF-alpha) protein. TNF-α is an adipokine that is involved in systemic inflammation and regulates immune cells in response to disease. Recombinant TNF-α is also called tasonermin , it is used as an immunostimulant and is the primary active ingredient in the European drug Beromun. Gold Biotechnology additionally has a His-tagged TNF-α, convenient for protein isolation experiments as well as a TNF-α variant which has been shown to express anti-tumor activity in mice as compared to normal murine TNF-α.
Showing 1-7 of 7 items.

FLT3LG, Human

Catalog ID Size Pricing
1130-05-10 10 μg $ 165.00
1130-05-100 100 μg $ 905.00
1130-05-500 500 μg $ 1,849.00

Description

FLT3LG is a hematopoietic cytokine whose activities are mediated by binding to the transmembrane glycoprotein Flt3. Flt3 was first discovered as a member of the class III subfamily of receptor tyrosine kinases (RTK) whose expression among hematopoietic cells was found to be restricted to highly enriched stem/progenitor cell populations. Additionally, class III RTKs include the receptors from SCF, CSF3 and PDGF. Not surprisingly, FLT3LG is also structurally related to CSF3 and SCF. All three cytokines have been shown to exist both as type I transmembrane proteins and as soluble proteins. The predominant human FLT3LG isoform is a transmembrane protein that can undergo proteolytic cleavage to generate a soluble form of the protein. An alternatively-spliced FLT3LG mRNA, encoding a soluble form of the human FLT3LG, has also been identified. FLT3LG is widely expressed in various human and mouse tissues. At the amino acid sequence level, human and mouse FLT3LG are approximately 72% identical and the two proteins exhibit cross-species activity. FLT3LG has been shown to synergize with a wide variety of hematopoietic cytokines to stimulate the growth and differentiation of early hematopoietic progenitors.

Product Specifications

Catalog ID 1130-05
MW ~17.6 kDa
Storage/Handling Store desiccated at -20°C.
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Packs & Pricing
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1130-05-10 3-4 Weeks 10 μg $ 165.00
1130-05-100 3-4 Weeks 100 μg $ 905.00
1130-05-500 3-4 Weeks 500 μg $ 1,849.00

LIF, Human

Catalog ID Size Pricing
1130-07-5 5 μg $ 115.00
1130-07-100 100 μg $ 709.00
1130-07-500 500 μg $ 1,465.00

Description

Leukemia Inhibitory Factor (LIF) is a lymphoid factor which promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF binds to the specific LIFR-α, which forms a heterodimer containing a GP130 signal transducing subunit.LIF is normally expressed in the trophectoderm of the developing embryo and has a number of other activities including cholinergic neuron differentiation, control of stem cell pluripotency, bone and fat metabolism, mitogenesis of certain factor dependent cell lines and promotion of megakaryocyte production in vivo. LIF is not required for human embryonic stem cell cultures.

Sterile Filtered White lyophilized powder

Product Specifications

Catalog ID 1130-07
MW ~19.7 kDa
Storage/Handling Store desiccated at -20°C.
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Packs & Pricing
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1130-07-5 3-4 Weeks 5 μg $ 115.00
1130-07-100 3-4 Weeks 100 μg $ 709.00
1130-07-500 3-4 Weeks 500 μg $ 1,465.00

LIF, Murine

Catalog ID Size Pricing
1330-07-5 5 μg $ 115.00
1330-07-100 100 μg $ 709.00
1330-07-500 500 μg $ 1,465.00

Description

Leukemia Inhibitory Factor (LIF) is a lymphoid factor which promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF binds to the specific LIFR-α, which forms a heterodimer containing a GP130 signal transducing subunit.LIF is normally expressed in the trophectoderm of the developing embryo and has a number of other activities including cholinergic neuron differentiation, control of stem cell pluripotency, bone and fat metabolism, mitogenesis of certain factor dependent cell lines and promotion of megakaryocyte production in vivo. While LIF is not required for human embryonic stem cell cultures, it is commonly used for mouse embryonic stem cell cultures.

Sterile Filtered White lyophilized powder

Product Specifications

Catalog ID 1330-07
MW ~19.9 kDa
Storage/Handling Store desiccated at -20°C.
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Packs & Pricing
,
1330-07-5 3-4 Weeks 5 μg $ 115.00
1330-07-100 3-4 Weeks 100 μg $ 709.00
1330-07-500 3-4 Weeks 500 μg $ 1,465.00

TNF-α (His), Human

Catalog ID Size Pricing
1130-01H-10 10 μg $ 115.00
1130-01H-100 100 μg $ 489.00
1130-01H-500 500 μg $ 1,019.00

Description

Tumor necrosis factor (or TNF-α), also called cachectin, is produced by neutrophils, activated lymphocytes, macrophages, NK-cells, LAK-cells, astrocyte endothelial cells, smooth muscle cells and some transformed cells. TNF occurs as a secreted, soluble form and as a membrane-anchored form, both of which are biologically active. The naturally occurring form of TNF is glycosylated, but nonglycosylated recombinant TNF has comparable biological activity. The biologically active native form of TNF is reportedly a trimer. Human and murine TNF has approximately 79% homology at the amino acid level and there is cross-reactivity between the two species. Two types of receptors for TNF, p55 and p75, have been described and virtually all cell types studied show the presence of one or both of these receptor types.

Product Specifications

Catalog ID 1130-01H
MW ~18.3 kDa
Storage/Handling Store desiccated at -20°C.
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Packs & Pricing
,
1130-01H-10 3-4 Weeks 10 μg $ 115.00
1130-01H-100 3-4 Weeks 100 μg $ 489.00
1130-01H-500 3-4 Weeks 500 μg $ 1,019.00

TNF-α (Variant), Human

Catalog ID Size Pricing
1130-012-10 10 μg $ 115.00
1130-012-100 100 μg $ 379.00
1130-012-500 500 μg $ 805.00

Description

Tumor necrosis factor (or TNF-α), also called cachectin, is produced by neutrophils, activated lymphocytes, macrophages, NK-cells, LAK-cells, astrocyte endothelial cells, smooth muscle cells and some transformed cells. TNF occurs as a secreted, soluble form and as a membrane-anchored form, both of which are biologically active. The naturally occurring form of TNF is glycosylated, but nonglycosylated recombinant TNF has comparable biological activity. The biologically active native form of TNF is reportedly a trimer. Human and murine TNF has approximately 79% homology at the amino acid level and there is cross-reactivity between the two species. Two types of receptors for TNF, p55 and p75, have been described and virtually all cell types studied show the presence of one or both of these receptor types.

The clinical use of the potent antitumor activity of TNF has been limited by the pro-inflammatory side effects including fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis and hemorrhage. Designing clinically applicable TNF mutants with low systemic toxicity has been an intense pharmacological interest. Human TNF variants, which bind to the murine TNF-R55 but not to the murine TNF-R75, exhibit retained anti-tumor activity and reduced systemic toxicity in mice compared with murine TNF, which binds to both murine TNF receptors. Based on these results, many TNF mutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro, and exhibited lower systemic toxicity in vivo.

Product Specifications

Catalog ID 1130-012
MW ~16.9 kDa
Storage/Handling Store desiccated at -20°C.
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Packs & Pricing
,
1130-012-10 3-4 Weeks 10 μg $ 115.00
1130-012-100 3-4 Weeks 100 μg $ 379.00
1130-012-500 3-4 Weeks 500 μg $ 805.00

TNF-α, Human

Catalog ID Size Pricing
1130-01-10 10 μg $ 115.00
1130-01-100 100 μg $ 355.00
1130-01-500 500 μg $ 749.00

Description

Tumor necrosis factor (or TNF-α), also called cachectin, is produced by neutrophils, activated lymphocytes, macrophages, NK-cells, LAK-cells, astrocyte endothelial cells, smooth muscle cells and some transformed cells. TNF occurs as a secreted, soluble form and as a membrane-anchored form, both of which are biologically active. The naturally-occurring form of TNF is glycosylated, but nonglycosylated recombinant TNF has comparable biological activity. The biologically active, native form of TNF is reportedly a trimer. Human and murine TNF has approximately 79% homology at the amino acid level and there is cross-reactivity between the two species. Two types of receptors for TNF, p55 and p75, have been described and virtually all cell types studied show the presence of one or both of these receptor types.

Product Specifications

Catalog ID 1130-01
MW ~17.5 kDa
Storage/Handling Store desiccated at -20°C.
View
Packs & Pricing
,
1130-01-10 In stock 10 μg $ 115.00
1130-01-100 3-4 Weeks 100 μg $ 355.00
1130-01-500 3-4 Weeks 500 μg $ 749.00

TNF-α, Murine

Catalog ID Size Pricing
1330-01-5 5 μg $ 115.00
1330-01-100 100 μg $ 745.00
1330-01-500 500 μg $ 1,539.00

Description

Tumor necrosis factor (or TNF-α), also called cachectin, is produced by neutrophils, activated lymphocytes, macrophages, NK-cells, LAK-cells, astrocyte endothelial cells, smooth muscle cells and some transformed cells. TNF can occur as a secreted, soluble form or as a membrane-anchored form, both of which are biologically active. Mouse TNF occurs as a membrane-anchored form. The naturally occurring form of TNF is glycosylated, but nonglycosylated recombinant TNF has comparable biological activity. The biologically active native form of TNF is reportedly a trimer. Human and murine TNF has approximately 79% homology at the amino acid level and there is cross-reactivity between the two species. Two types of receptors for TNF, p55 and p75, have been described and virtually all cell types studied show the presence of one or both of these receptor types.

Product Specifications

Catalog ID 1330-01
MW ~17.3 kDa
Storage/Handling Store desiccated at -20°C.
View
Packs & Pricing
,
1330-01-5 In stock 5 μg $ 115.00
1330-01-100 3-4 Weeks 100 μg $ 745.00
1330-01-500 3-4 Weeks 500 μg $ 1,539.00

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