F_Products

Basic fuchsin is a fluorescent dye composed of rosaniline, magenta II, pararosaniline and new fuschsine. Basic fuchsin staining is certified to use for the detection of acid-fast bacilli and is commonly used in the Ziehl Neelsen staining method.

This dye has also been shown to stain tubercle Bacillus and to compare E. coli and Aerobacter aerogenes.

D-Fructose 6-phosphate, disodium salt dihydrate is a glycolytic intermediate produced upon isomerization of glucose-6-phosphate. It may be used to characterize enzymes of the glycolytic pathway and differentiate between them.

FAM19A2 (TAFA-2) is chemokine-like protein containing ten cysteine residues that are conserved amongst the FAM19A (TAFA) family. This family of proteins was first identified by using a clustering algorithm on uncharacterized cDNA sequences and found to be distantly related to C-C motif chemokines, such as CCL3. FAM19A2 is expressed predominantly in the CNS, with very low expression levels detected in colon and spleen. Expression levels of FAM19A2 are highest in the occipital and frontal cortex and it is believed to be expressed constitutively. FAM19A2 is hypothesized to function as a brain-specific chemokine that regulates immune response in the CNS, as a neurokine that modulates immune response, or as a control of axonal sprouting following brain injury.

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Faropenem sodium is an ultra broad-spectrum β-lactam of the penem antibiotic class. It has been shown to be β-lactamase resistant and is especially effective against anaerobic bacteria responsible for oral infections, but targets a variety of gram-positive and gram-negative bacteria. Faropenem sodium is freely soluble in water.

FGF10/KGF2 is a member of the Fibroblast Growth Factor family of proteins. KGF2 cDNA encodes a 208 amino acid residue protein with a hydrophobic amino-terminal signal peptide. Human KGF2 shares 92% and 95% amino acid sequence identity with mouse and rat KGF2, respectively. In the FGF family, KGF2 is most closely related to FGF7 (KGF1), FGF3 and FGF22 (see additional information). The expression of KGF2 transcript has been shown to be most abundant in the embryo and adult lung. Recombinant KGF2 has been shown to be mitogenic for epithelial and epidermal cells but not fibroblasts. KGF2 may play unique roles in brain and lung development, wound healing and limb bud formation.

FGF10/KGF2 is a member of the Fibroblast Growth Factor family of proteins. KGF2 cDNA encodes a 208 amino acid residue protein with a hydrophobic amino-terminal signal peptide. Human KGF2 shares 92% and 95% amino acid sequence identity with mouse and rat KGF2, respectively. In the FGF family, KGF2 is most closely related to FGF7 (KGF1), FGF3 and FGF22 (see additional information). The expression of KGF2 transcript has been shown to be most abundant in the embryo and adult lung. Recombinant KGF2 has been shown to be mitogenic for epithelial and epidermal cells but not fibroblasts. KGF2 may play unique roles in brain and lung development, wound healing and limb bud formation.

FGF10/KGF2 is a member of the Fibroblast Growth Factor family of proteins. KGF2 cDNA encodes a 208 amino acid residue protein with a hydrophobic amino-terminal signal peptide. Human KGF2 shares 92% and 95% amino acid sequence identity with mouse and rat KGF2, respectively. In the FGF family, KGF2 is most closely related to FGF7 (KGF1), FGF3 and FGF22 (see additional information). The expression of KGF2 transcript has been shown to be most abundant in the embryo and adult lung. Recombinant KGF2 has been shown to be mitogenic for epithelial and epidermal cells but not fibroblasts. KGF2 may play unique roles in brain and lung development, wound healing and limb bud formation.

FGF13 is a member of the Fibroblast Growth Factor family of proteins. It is one of four FGFs that act as intracellular signaling molecules, independent of FGF receptors. They have instead been shown to interact with voltage-gated ion channels and the MAPK scaffold protein, islet-brain 2. FGF13 is expressed in the developing and adult central nervous system and acts to stabilize microtubules. It is required for axon and leading process development, as well as neuronal migration. It is believed to be a candidate gene for syndromal and nonspecific forms of X-chromosome-linked intellectual disability (XLID).

FGF18 is a member of the Fibroblast Growth Factor family of proteins. FGF18 has been shown in vitro to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggest that this protein is a pleiotropic growth factor that stimulates proliferation in tissues such as the liver and small intestine. FGF18 acts as a trophic factor for elastic chondrocytes in vivo and articular chondrocytes cultured in vitro and plays an autocrine role in normal articular cartilage repair. FGF18 –/– mice have decreased expression of osteogenic markers and delayed long-bone ossification. FGF18 has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. It is most closely related to FGF8 and FGF17 (see additional information).

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Rat Fibroblast Growth Factor 18
FGF18

FGF18 is a member of the Fibroblast Growth Factor family of mitogenic proteins. FGF18 has been shown in vitro to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggest that this protein is a pleiotropic growth factor that stimulates proliferation in tissues such as the liver and small intestine. FGF18 acts as a trophic factor for elastic chondrocytes in vivo and articular chondrocytes cultured in vitro and plays an autocrine role in normal articular cartilage repair. It is most closely related to FGF8 and FGF17 (see additional information).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

FGF19 is a member of the Fibroblast Growth Factor family of proteins. It is in the same endocrine signaling subfamily as FGF21 and FGF23 and is the human ortholog of mouse FGF15. FGF19 is a heparin-dependent ligand and binds exclusively to FGFR4. It is essential for brain and heart development, as well as the metabolism of bile acid, hepatic protein, and glycogen. FGF19 mRNA is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line.

FGF21 is a member of the Fibroblast Growth Factor family of proteins. It is in the same endocrine signaling subfamily as FGF19 and FGF23. FGF21 is a heparin-binding ligand for FGFR1c and FGFR4 that requires the presence of beta-klotho. Expression of FGF21 mRNA has been observed in the liver, the thymus, and several types of adipose tissue. It has been shown to stimulate glucose incorporation in differentiated adipocytes, independent of insulin activity. It has been suggested that FGF21 also acts as key regulator in the adaptation to stress.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

FGF21 is a member of the Fibroblast Growth Factor family of proteins. It is in the same endocrine signaling subfamily as FGF19 and FGF23. FGF21 is a heparin-binding ligand for FGFR1c and FGFR4 that requires the presence of beta-klotho. Expression of FGF21 mRNA has been observed in the liver, the thymus, and several types of adipose tissue. It has been shown to stimulate glucose incorporation in differentiated adipocytes, independent of insulin activity. It has been suggested that FGF21 also acts as key regulator in the adaptation to stress.

FGF21 is a member of the Fibroblast Growth Factor family of proteins. It is in the same endocrine signaling subfamily as FGF19 and FGF23. FGF21 is a heparin-binding ligand for FGFR1c and FGFR4 that requires the presence of beta-klotho. Expression of FGF21 mRNA has been observed in the liver, the thymus, and several types of adipose tissue. It has been shown to stimulate glucose incorporation in differentiated adipocytes, independent of insulin activity. It has been suggested that FGF21 also acts as key regulator in the adaptation to stress.

FGF23 is a member of the Fibroblast Growth Factor family of proteins. In the FGF family, FGF23 is most closely associated with FGF15/19 and FGF21 (see additional information). FGF23 shares 71% homology with mouse Fgf23 at the amino acid level. FGF23 is produced by osteocytes and osteoblasts in response to high circulating phosphate levels, elevated parathyroid hormone, and circulatory volume loading. It functions as an endocrine phosphatonin by suppressing circulating phosphate levels. FGF23 interaction with renal proximal tubular epithelium decreases the renal resorption of phosphate by down regulating phosphate transporters and by suppressing vitamin D production. It also decreases the intestinal absorption of phosphate.

FGF4 is a member of the Fibroblast Growth Factor family of proteins and was first identified by its oncogenic activity. It plays an important role in embryonic development, acting as an autocrine or paracrine ligand through the FGFR 1c, 2c, 3c, and 4 receptors to support stem cell self-renewal. It is believed that FGF4, with the combined activity one or more apical ectodermal ridge FGFs (FGF2, FGF4, FGF8, and FGF9) works in a positive feedback loop with SHH to control limb development.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

FGF7/KGF1 is a member of the Fibroblast Growth Factor family of proteins. In the FGF family, FGF7 is most closely related to FGF10 (KGF2), FGF3 and FGF22 (see additional information). Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues by promoting cellular proliferation and differentiation. FGF7/KGF1 is mitogen factor specific for epithelial cells and keratinocytes and signals through Fibroblast Growth Factor Receptor-2b (FGFR-2b) and plays an important role in kidney and lung development, angiogenesis and wound healing.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Murine Fibroblast Growth Factor 7
FGF7
KGF1
Keratinocyte Growth Factor 1

FGF7/KGF1 is a member of the Fibroblast Growth Factor family of proteins. In the FGF family, FGF7 is most closely related to FGF10 (KGF2), FGF3 and FGF22 (see additional information). Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF7/KGF1 is mitogen factor specific for epithelial cells and keratinocytes and signals through Fibroblast Growth Factor Receptor-2b (FGFR-2b) and plays an important role in kidney and lung development, angiogenesis and wound healing.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

FGF8 is a member of the Fibroblast Growth Factor family of proteins. These proteins play a crucial role during prenatal development and postnatal growth. In mice, there are 8 known alternate spliced forms of FGF8: FGF8A-H. The human and murine FGF8A and B proteins are 100% identical while FGF8E and F proteins are 98% identical between human and mouse. FGF8 targets mammary carcinoma cells and other cells expressing the FGF receptors. In the FGF family, FGF8 is most closely associated with FGF17 and FGF18 (see additional information).

FGF9 is a member of the Fibroblast Growth Factor family of proteins. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF9 targets glial cells, astrocytes and other cells that express FGFR 1c, 2c, 3b, 3c and 4. FGF9 is a potent mitogen for both prostatic epithelial and stromal cells in culture and is an abundant, secreted growth factor that can act as both a paracrine mitogen for epithelial cells and as an autocrine mitogen for stromal cells. There is a 99% amino acid sequence homology between human, mouse and rat FGF9 proteins. In the FGF family, FGF9 is most closely associated with FGF16 and FGF20 (see additional information).