Detergents

Detergents, also called surfactants, play a vital role in molecular biology techniques, allowing researchers the ability to lyse cells or solubilize membrane proteins. GoldBio provides high quality ionic, nonionic and zwitterionic detergents that are ideal for a variety research methods but at a fraction of the price of other commercially available detergents. GoldBio’s selection includes CHAPS, DDM, BRIJ-35, octylthiogalactoside and octylglucoside among others, many of which are nondenaturing.
Showing 1-15 of 15 items.

1,2-Dipalmitoyl-rac-glycero-3-phosphocholine

Catalog ID Size Pricing
D-226-500 500 mg $ 250.00
D-226-1 1 g $ 467.00
D-226-2.5 2.5 g $ 1,088.00

Description

1,2-Dipalmitoyl-rac-glycero-3-phosphocholine is a phospholipid with two palmitic acids and is the racemic mixture of Dipalmitoylphosphatidylcholine (also known as Colfosceril palmitate or DPPC). The phosphocholine head is sensitive to electric charges at the membrane surface when bound to pure phospholipids. When added to a solution containing charged ions, this sensitivity can shift the nitrogen cation away from a lack of positive charge or towards a positive charge in solution. In a research environment, it is useful in studying changes of biological membranes and liposomes. Because of its ability to form simple phospholipid bilayers, it is useful in computer modeling of bilayers in dynamic situations. Modeling can also be extended to interactions between DPPC and other biologically active molecules (like pharmaceuticals) as an analog for the same naturally occurring process. It is also useful in the formation of reconstituted HDL particles.

Product Specifications

Catalog ID D-226
CAS # 2644-64-6
MW 734.04 g/mol
Storage/Handling Store at -20°C. Protect from light.
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D-226-500 2-3 Weeks 500 mg $ 250.00
D-226-1 In stock 1 g $ 467.00
D-226-2.5 2-3 Weeks 2.5 g $ 1,088.00

Cetylpyridinium chloride

Catalog ID Size Pricing
C-120-100 100 g $ 76.00

Description

Cetylpyridinium chloride is a cationic quaternary ammonium compound that has been used to eliminate oral pathogens. It has shown a high degree of efficacy towards gram-positive, gram-negative bacteria and some pathogenic fungi.

Cetylpyridinium chloride functions as a surfactant, reducing the surface tension between pathogenic membranes and their environments. Greater interaction between the membrane and environment disrupts the cell membrane and osmoregulation. Compromising the membrane ultimately results in cell death.

Product Specifications

Catalog ID C-120
CAS # 6004-24-6
MW 358.00 g/mol
UN Number 2811
Item Class 6.1
Group Number II
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C-120-100 2-3 Weeks 100 g $ 76.00

CHAPS

Catalog ID Size Pricing
C-080-1 1 g $ 35.00
C-080-5 5 g $ 65.00
C-080-10 10 g $ 79.00
C-080-25 25 g $ 155.00
C-080-100 100 g $ 375.00
C-080-250 250 g $ 745.00
C-080-500 500 g $ 1,335.00

Description

CHAPS, also known as ((3-cholamidopropyl)dimethylammonio)-1-propanesulfonate, is a zwitterionic surfactant primarily used to solubilize membrane proteins and other macromolecules.

Oftentimes, mild detergents are used in cell lysis applications by interfering with membrane interactions.

Product Specifications

Catalog ID C-080
CAS # 75621-03-3
MW 614.88 g/mol
Grade ULTRA PURITY GRADE
Storage/Handling Store at 4°C.
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C-080-1 In stock 1 g $ 35.00
C-080-5 In stock 5 g $ 65.00
C-080-10 In stock 10 g $ 79.00
C-080-25 In stock 25 g $ 155.00
C-080-100 In stock 100 g $ 375.00
C-080-250 In stock 250 g $ 745.00
C-080-500 In stock 500 g $ 1,335.00

Chlorhexidine

Catalog ID Size Pricing
C-615-1 1 g $ 107.00
C-615-5 5 g $ 422.00

Description

Chlorhexidine is a cationic polybisbiguanide used as a detergent as well as a bactericidal, anti-viral and antifungal agent. It has been used against an array of oral pathogens, with a high effectiveness toward gram-negative bacteria.

Chlorhexidine, when placed into physiological pH, dissociates into its cationic form and binds to the negatively charged bacterial wall. This binding will cause cytosolic leakage at low concentrations and lytic effects at high chlorohexidine concentrations. However, chlorhexidine activity can be halted upon interaction with anionic compounds.

Product Specifications

Catalog ID C-615
CAS # 55-56-1
MW 505.45 g/mol
UN Number 3077
Item Class 9
Group Number III
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C-615-1 2-3 Weeks 1 g $ 107.00
C-615-5 2-3 Weeks 5 g $ 422.00

Chlorhexidine diacetate salt

Catalog ID Size Pricing
C-250-25 25 g $ 214.00

Description

Chlorhexidine diacetate salt is a diacetate derivative of a cationic polybisbiguanide that has bactericidal, anti-fungal and anti-viral activity. It has also been used for in vivo pharmacokinetic research to investigate drug release rates.

Chlorhexidine, when placed into physiological pH, dissociates into its cationic form and binds to the negatively charged bacterial wall. This binding will cause cytosolic leakage at low concentrations and lytic effects at high chlorohexidine concentrations. However, chlorhexidine activity can be halted upon interaction with anionic compounds.

Product Specifications

Catalog ID C-250
CAS # 56-95-1
MW 625.55 g/mol
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C-250-25 2-3 Weeks 25 g $ 214.00

Chlorhexidine HCl

Catalog ID Size Pricing
C-725-5 5 g $ 60.00
C-725-25 25 g $ 220.00

Description

Chlorhexidine HCl is the cationic salt form of chlorhexidine, a bactericidal detergent. Chlorhexidine HCl has strong bactericidal activity and is used for in vitro bactericidal assays as a positive control.

The compound functions as a bactericidal agent by interacting with the negatively charged bacterial cell wall. Contact of the cationic salt with the cell wall causes cytosolic leakage at low chlorohexidine HCl concentrations and cell lysis at higher concentrations. Duration of antibacterial effects has been shown to be enhanced by incorporating chlorhexidine HCl into human albumin microspheres. This lengthened antibacterial activity against Escheria coli, Staphylococcus aureus and Pseudomonas aeruginosa.

Product Specifications

Catalog ID C-725
CAS # 3697-42-5
MW 578.37 g/mol
UN Number 3077
Item Class 9
Group Number III
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C-725-5 2-3 Weeks 5 g $ 60.00
C-725-25 2-3 Weeks 25 g $ 220.00

Deoxycholic Acid Sodium Salt

Catalog ID Size Pricing
D-070-25 25 g $ 90.00
D-070-100 100 g $ 238.00

Description

Deoxycholic acid (typically abbreviated DOC) is a bile acid typically found in the intestine. Bile acids typically cause DNA damage and can lead to an increase in mutations. Deoxycholic acid can be covalently attached to glycol chitosan as a delivery system in nanotechnological applications. Many other applications, such as those to perform 1,4-addition of diethylzinc to acyclic enones, requires the binding of Deoxycholic acid to other molecules to create ligands that are conducive to addition of metals to certain enones.

In more general applications, Deoxycholic acid is used to increase the solubilization of cells. Deoxycholic acid is typically used as an ingredient in the creation of RIPA buffers, added in concentrations between 0.5% and 2.5%. These buffers are typically used to extract proteins from membranes and cytoplasm. This method of extraction contains the ionic detergent SDS and is useful for the disruption of nuclear membranes and their associated proteins. Proteins extracted via this initial procedure can be used in other analytical procedures like western blot or a BCA protein assay.

Product Specifications

Catalog ID D-070
CAS # 302-95-4
MW 414.55 g/mol
Storage/Handling Store desiccated at room temperature.
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D-070-25 In stock 25 g $ 90.00
D-070-100 2-3 Weeks 100 g $ 238.00

Digitonin Special Grade (water soluble)

Catalog ID Size Pricing
D-180-250 250 mg $ 125.00
D-180-1 1 g $ 299.00
D-180-2.5 2.5 g $ 615.00
D-180-5 5 g $ 1,129.00
D-180-10 10 g $ 2,079.00

Description

Product Specifications

Catalog ID D-180
CAS # 11024-24-1
MW 1229.31 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store desiccated at -20°C.
UN Number 2811
Item Class 6.1
Group Number II
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D-180-250 In stock 250 mg $ 125.00
D-180-1 In stock 1 g $ 299.00
D-180-2.5 In stock 2.5 g $ 615.00
D-180-5 In stock 5 g $ 1,129.00
D-180-10 In stock 10 g $ 2,079.00

Glycochenodeoxycholic acid

Catalog ID Size Pricing
G-540-25 25 g $ 312.00

Description

Glycochenodeoxycholic acid (GCDC) is a bile salt that is used as an anionic detergent to solubilize lipids. In other applications GCDC can be used to induce hepatocyte apoptosis and inhibit calcium phosphate precipitation in vitro. GCDC is also used in applications analyzing the damage done to DNA by other bile acids.

Product Specifications

Catalog ID G-540
CAS # 640-79-9
MW 471.61 g/mol
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G-540-25 2-3 Weeks 25 g $ 312.00

Glycochenodeoxycholic acid, sodium salt

Catalog ID Size Pricing
G-590-5 5 g $ 204.00
G-590-10 10 g $ 316.00
G-590-25 25 g $ 717.00
G-590-50 50 g $ 1,062.00

Description

Glycochenodeoxycholic acid (GCDC) is a bile salt that is used as an anionic detergent to solubilize lipids. In other applications GCDC can be used to induce hepatocyte apoptosis and inhibit calcium phosphate precipitation in vitro. GCDC is also used in applications analyzing the damage done to DNA by other bile acids.

Product Specifications

Catalog ID G-590
CAS # 16564-43-5
MW 471.61 g/mol
Storage/Handling Store at 4°C.
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G-590-5 2-3 Weeks 5 g $ 204.00
G-590-10 2-3 Weeks 10 g $ 316.00
G-590-25 2-3 Weeks 25 g $ 717.00
G-590-50 2-3 Weeks 50 g $ 1,062.00

Hexadecylpyridinium bromide

Catalog ID Size Pricing
H-615-100 4 x 25 g $ 80.00

Description

Hexadecylpyridinium bromide is a cationic surfactant capable of bactericidal activity and has been used for ion exchange. As a bactericidal agent, it reduces the surface tension between pathogenic membranes and their environments. This interaction disrupts membrane integrity and osmoregulation, leading to cell lysis.

Hexadecylpyridinium bromide has also been shown to quickly and efficiently remove metal ions from solutions. The compound removes cations from solution through a cation/surfactant complex which precipitates from an aqueous phase into an organic phase and can subsequently be extracted. Hexadecylpyridinium bromide is an effective ion exchange agent for extracting DNA and proteins.

Product Specifications

Catalog ID H-615
CAS # 140-72-7
MW 384.44 g/mol
UN Number 2811
Item Class 6.1
Group Number II
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H-615-100 2-3 Weeks 4 x 25 g $ 80.00

n-Dodecyl-B-D-maltoside (DDM)

Catalog ID Size Pricing
DDM5 5 g $ 145.00
DDM10 10 g $ 275.00
DDM25 25 g $ 635.00
DDM50 50 g $ 1,129.00
DDM100 100 g $ 2,049.00

Description

The primary attribute of DDM is its capability to extract hydrophobic proteins while maintaining the solution-phase protein conformation. DDM also allows the protein to be reformed following denaturization. Most membrane-bound proteins are α-helix bundles, which are less robust to changes in their cellular environment. DDM offers a detergent capable of preserving these proteins. This is in contrast to other, harsher ionic detergents that destabilize and permanently denature α-helical membrane-bound proteins. DDM has been used to solubilize the multidrug-transporter protein, EmrE, as well as the nucleoside-specific porin protein, Tsx.

Product Specifications

Catalog ID DDM
CAS # 69227-93-6
MW 510.63 g/mol
Storage/Handling Store at -20°C. Protect from light.
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DDM5 In stock 5 g $ 145.00
DDM10 In stock 10 g $ 275.00
DDM25 In stock 25 g $ 635.00
DDM50 In stock 50 g $ 1,129.00
DDM100 In stock 100 g $ 2,049.00

Octylglucoside, Ultra Pure

Catalog ID Size Pricing
O-110-5 5 g $ 115.00
O-110-10 10 g $ 205.00
O-110-25 25 g $ 309.00
O-110-50 50 g $ 589.00

Description

Octylglucoside is a nonionic, mild detergent used to isolate membrane proteins in the native state. It can easily be removed during final extractions by dialysis.

Characteristics that contribute to this detergent’s usefulness are its water solubility, chemical structure and small-sized micelles.

Octylglucoside also provides higher resolution of proteins in 2D electrophoresis.

Product Specifications

Catalog ID O-110
CAS # 29836-26-8
MW 292.38 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store desiccated at -20°C. Protect from light.
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O-110-5 In stock 5 g $ 115.00
O-110-10 In stock 10 g $ 205.00
O-110-25 In stock 25 g $ 309.00
O-110-50 In stock 50 g $ 589.00

Octylthioglucoside

Catalog ID Size Pricing
O-130-5 5 g $ 135.00
O-130-10 10 g $ 239.00
O-130-25 25 g $ 405.00
O-130-50 50 g $ 739.00

Description

Octylthioglucoside is a nonionic detergent that has been used to isolate membrane proteins without inactivation. This product is effective in a variety of protein solubilization and cell lysis processes. And detergents of this nature are ideal when studying the conformation and structure of proteins because the secondary and tertiary structures remain intact.

Compared to octylglucoside, octylthioglycoside is more stable. And it is stable in aqueous solution and easily removed by dialysis. This product is intended for use as a detergent to solubilize membrane-bound proteins in their native state.

Product Specifications

Catalog ID O-130
CAS # 85618-21-9
MW 308.44 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at -20°C. Protect from light.
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O-130-5 In stock 5 g $ 135.00
O-130-10 In stock 10 g $ 239.00
O-130-25 In stock 25 g $ 405.00
O-130-50 In stock 50 g $ 739.00

Tridecyl beta-D-maltopyranoside

Catalog ID Size Pricing
T-290-100 100 mg $ 78.00
T-290-250 250 mg $ 119.00
T-290-500 500 mg $ 194.00
T-290-1 1 g $ 288.00
T-290-2 2 g $ 525.00

Description

Tridecyl b-D-maltopyranoside is a disaccharide derivative and glycoside which is applied as a non-ionic detergent and surfactant. In studies on membrane protein crystallization, Tridecyl b-D-maltopyranoside proved to be an effective detergent for maintaining protein solubility but necessitates the presence of salt. Tridecyl b-D-maltopyranoside has a longer chain length than Decyl β-D-maltopyranoside, another detergent used on membrane protein crystallization. Decyl β-D-maltopyranoside has been used in micellar electrokinetic chromatography to study enantiomer separation of drugs.

Product Specifications

Catalog ID T-290
CAS # 93911-12-7
MW 524.64 g/mol
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T-290-100 2-3 Weeks 100 mg $ 78.00
T-290-250 2-3 Weeks 250 mg $ 119.00
T-290-500 2-3 Weeks 500 mg $ 194.00
T-290-1 2-3 Weeks 1 g $ 288.00
T-290-2 2-3 Weeks 2 g $ 525.00

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