D_Products

Difloxacin is a fluoroquinolone antibiotic targeting gram-negative and gram-positive bacteria as well as Mycobacterium tuberculosis. Additionally, it has shown efficacy against Chlamydia trachomatis. Difloxacin has been used to study the effects of magnesium supplementation on quinolone-induced damage in animal models. Difloxacin HCl is freely soluble in aqueous solution.

Dihydrostreptomycin is an aminoglycoside antibiotic targeting gram-positive bacteria and Mycobacterium species. It is a derivative of streptomycin and commonly used to study aminoglycoside uptake. Dihydrostreptomycin sulfate is freely soluble in aqueous solution.

Dihydrotanshinone I is a compound extracted from the plant Salvie miltorrhiza Bunge. It is used as a gram positive antibacterial and anti-cancer compound. In both in vivo and in vitro research, dihydrotanshinone I generated reactive oxygen species which trigger apoptosis in bacteria and cancer cells.

Dihydrotanshinone I triggers apoptosis by directly damaging DNA and preventing further replication or by activating p38 mitogen-activated protein kinases (p38 MAPK). This class of protein kinase engages apoptosis by activating caspases which are proteases that induce cell death. Dihydrotanshinone I has also been shown to inhibit cell growth past the G1 stage and prevent blood vessel formation by inhibiting hypoxia-inducible factor (HIF-1) activity.

Dimethyl 1,4-Cubanedicarboxylate is a reagent used in chemical synthesis.

Dimetridazole is a nitroimidazole antibiotic useful against protozoa and bacteria. It has shown great efficacy against Campylobacter species. Dimetridazole has been useful in studying nitroimidazole mechanisms and is slightly soluble.

Dirithromycin is a lipid soluble prodrug derivative of the macrolide antibiotic 9S-erythromycyclamine. It has a sizeable antibiotic activity range, being effective against gram positive and gram negative bacteria. It is highly insoluble in acidic and alkaline conditions and will spontaneously hydrolyze into the active erythromycyclamine form.

Macrolide antibiotics are composed of a macrocyclic lactone ring attached to one or more deoxy sugars. They inhibit bacterial protein synthesis by irreversibly binding the P site of the 50s ribosome, preventing peptide bond formation and translocation.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

DL-3-Tyrosine has a hypotensive effect on blood pressure and is converted to dopamine in rats. It can also be used as a reagent for chemical synthesis.

DL-Arginine is an alpha amino-acid and can be found as a metabolite and as a reagent for biological molecules.

DL-ethionine changes behavior of hepatic functions by working as a carcinogenic agent that induces cholangiocarcinogensis in vivo and can be used to induce oxidative stress on the liver to measure antioxidant enzymatic activity. In the pancreas it destroys acinar cells and eventually induces pancreatitis in rats. DL-ethionine also inhibits incorporation of amino acids, like methionine and glycine, into rat protein in vivo and interferes with the use of adenosine triphosphate (ATP) in cells.

DL-Homocysteic acid is a glutamic acid analog and a receptor agonist of NMDA. It disrupts calcium homeostasis and induces degeneration of spinal motor neurons, and has a cytotoxic effect on the central nervous system. DL-Homocysteic acid also induces oxidative stress in brain tissues and inhibits arterial pressure, heart rate and diaphragm electromyogram activity. Complexes with DL-Homocysteic acid and cations like sodium and zinc have been synthesized.

DL-Indole-3-lactic acid is a reagent used in chemical synthesis. It is one of the building blocks of the sweetener Monatin and Fab I inhibitors. It is a tryptophan metabolite of Bifidobacterium.

GoldBio’s DL39 (DE3) Chemically Competent E. coli cells are engineered with a T7 expression system to transform and express proteins in order to label residues such as phenylalanine or leucine. DL39 (DE3) Chemically Competent E. coli cells are deficient in the aromatic (TyrB), branched-chain (JIvE), and aspartate (AspC) transaminases and are auxotrophic for aspartic acid, isoleucine, leucine, phenylananine, tyrosine, and valine residues.

Product Specifications
Competent cell type: Chemically Competent
Derivative of: DL39
Species: E. coli
Transformation efficiency: ≥1 x 10⁷ cfu/µg pUC19 DNA
Blue/white screening: Yes

Luciferin is a common bioluminescent reporter used for in vivo imaging of the expression of the luciferase . This substrate for the firefly luciferase enzyme utilizes ATP and Mg2+ as cofactors and emits a characteristic yellow-green emission in the presence of oxygen, which shifts to red light in vivo at 37°C.

Luciferin is a common reagent used throughout the biotechnology field and specifically for in vivo imaging. Luciferase labeled tumor cells, stem cells or infectious diseases are often inoculated into research animals such as rats or mice for investigation. The injection of luciferin allows for the real-time, noninvasive monitoring of disease progression and/or drug efficacy in these model systems through Bioluminescence Imaging (BLI).

DMNPE-caged luciferin can be used to measure intracellular functions since it readily crosses cell membranes. Once it is inside the cell, active luciferin can be released by UV light or by the action of endogenous intracellular esterases. DMNPE-caged luciferin makes it easier to follow the changes in gene expression in live cells. It can also be used in combination with DMNPE-caged ATP.

Dimethylsulfoxide (DMSO) is a very polar organic compound that is useful in organic chemistry for solubilizing organic and inorganic compounds. DMSO is also used as a cryoprotectant for cell media, preventing the formation of ice crystals, which would otherwise damage cells. DMSO can be used in PCR reactions to inhibit the self-complementation of DNA or PCR primers and increase amplification, especially for DNA sequences, which have GC rich sequences.

DNase I (Deoxyribonuclease I) is a dialyzed lyophilized powder from bovine pancreas that has been purified by chromatography.

Bovine pancreatic deoxyribonuclease (DNase) is an endonuclease, which splits phosphodiester linkages preferentially adjacent to a pyrimidine nucleotide yielding polynucleotides with a free hydroxyl group at the 3' position and a phosphate group at the 5' position. The optimum pH is 7.8.

DNase I is activated by bivalent metals and inhibited by chelating agents such as EDTA and SDS. DNase I can be stabilized against proteolytic digestion by 5mM Ca2+.

DNase I (Deoxyribonuclease I) is a dialyzed lyophilized powder from bovine pancreas that has been purified by chromatography.

Bovine pancreatic deoxyribonuclease (DNase) is an endonuclease which splits phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide yielding polynucleotides with a free hydroxyl group at the 3' position and phosphate group at the 5' position. The optimum pH is 7.8.

DNase I is activated by bivalent metals, and inhibited by chelating agents such as EDTA and SDS. DNase I can be stabilized against proteolytic digestion by 5mM Ca 2+.

DNase I (Deoxyribonuclease I) is a dialyzed lyophilized powder from bovine pancreas that has been purified by chromatography.

Bovine pancreatic deoxyribonuclease (DNase) is an endonuclease which splits phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide yielding polynucleotides with a free hydroxyl group at the 3' position and phosphate group at the 5' position. The optimum pH is 7.8.

DNase I is activated by bivalent metals, and inhibited by chelating agents such as EDTA and SDS. DNase I can be stabilized against proteolytic digestion by 5 mM Ca²⁺.

GoldBio’s 2’-Deoxynucleoside 5’-triphosphate mix is an aqueous solution containing dATP, dCTP, dGTP and dTTP, each at a final concentration of 10mM. This mixture has been tested for performance in a wide size-range of PCR templates with Taq and Pfu DNA polymerases.

The dNTP solution is ideal for PCR, cDNA synthesis, DNA sequencing and labeling procedures, and it has been performance tested with Q-PCR and long PCR (30 kb).

Doxorubicin HCl is an anthracycline antibiotic that inhibits cancer progression by suppressing DNA replication. It is the 12-hydroxylated form of daunorubicin and causes DNA intercalation. It also inhibits topoisomerase II. Doxorubicin is researched for its efficacy against non-Hodgkin’s lymphoma, multiple myeloma, acute leukemias, Kaposi sarcoma, Wilm tumor, Ewing sarcoma, and cancers of the breast, lung, ovary, endometrium, and adrenal cortex. Doxorubicin is an MRP-1 substrate and has been used in drug-resistance studies.